From the Department of Radiology (W.L., N.B., G.C., D.S.H., C.Y.), University of Washington, Seattle.
Division of Vascular Surgery, Department of Surgery (H.W., T.H.), University of Washington, Seattle.
Arterioscler Thromb Vasc Biol. 2019 Jun;39(6):1018-1025. doi: 10.1161/ATVBAHA.119.312513.
Atherosclerotic cardiovascular disease remains a worldwide epidemic and one of the leading causes of death nowadays. Vessel wall imaging can be used to understand the development and progression of atherosclerosis, but it is rarely done because of the high cost. We recently identified the Osteoarthritis Initiative, a large prospective cohort study of knee osteoarthritis, which might serve as a valuable source for atherosclerosis research with its serial knee magnetic resonance imaging data. We have found that these images are suitable for vessel wall image analysis of the lower extremity arteries. Here, we will introduce the Osteoarthritis Initiative data set and explain why it could be used for cardiovascular research purposes. Also, we will briefly comment on peripheral artery atherosclerosis as it is covered in the Osteoarthritis Initiative image data set and review the use of vessel wall imaging for studying atherosclerosis. We think data mining of imaging studies, not originally designed on cardiovascular research, can not only maximize the value of the imaging data set but also boost our understanding of atherosclerosis.
动脉粥样硬化性心血管疾病仍然是一种全球性的流行疾病，也是当今主要的死亡原因之一。血管壁成像可用于了解动脉粥样硬化的发展和进展，但由于成本高，很少进行这种成像。我们最近确定了骨关节炎倡议，这是一项针对膝关节骨关节炎的大型前瞻性队列研究，由于其连续的膝关节磁共振成像数据，它可能成为动脉粥样硬化研究的有价值的资源。我们发现这些图像适用于下肢动脉的血管壁图像分析。在这里，我们将介绍骨关节炎倡议数据集，并解释为什么它可以用于心血管研究目的。此外，我们还将简要讨论外周动脉粥样硬化，因为它涵盖在骨关节炎倡议图像数据集中，并回顾使用血管壁成像研究动脉粥样硬化。我们认为，对原本不是为心血管研究设计的成像研究进行数据挖掘，不仅可以最大限度地提高成像数据集的价值，还可以加深我们对动脉粥样硬化的认识。
