Heilongjiang Key Laboratory for Zoonosis, College of Veterinary Medicine, Northeast Agricultural University, Harbin, China.
Key Laboratory of Zoonosis of Ministry of Agriculture, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Trends Parasitol. 2019 Jun;35(6):436-451. doi: 10.1016/j.pt.2019.04.004. Epub 2019 May 7.
Enterocytozoon bieneusi is the most common cause of human microsporidiosis and it also infects a wide range of mammals and birds worldwide. The role of animals in the transmission of this parasite to humans and its public health importance remain poorly elucidated. This review summarizes all E. bieneusi genotypes identified thus far based on sequence analysis of the ribosomal internal transcribed spacer (ITS) from specimens obtained from humans, domestic and wild animals, and water sources; it examines genotypes, host and geographical distribution, analyzes inter- and intragenotype group host specificity, and interprets the public health significance of genotype groups and major zoonotic genotypes, with the goal of improving our understanding of host specificity in E. bieneusi and its implications for interspecies and zoonotic transmission.
肠微孢子虫是人类微孢子虫病最常见的病原体，它还感染了全球范围内的广泛哺乳动物和鸟类。动物在该寄生虫传播给人类中的作用及其公共卫生重要性仍未得到充分阐明。本综述根据从人类、家养和野生动物以及水源中获得的标本的核糖体内部转录间隔区（ITS）序列分析，总结了迄今为止鉴定的所有肠微孢子虫基因型；它检查了基因型、宿主和地理分布，分析了基因型内和基因型间的宿主特异性，并解释了基因型组和主要人畜共患病基因型的公共卫生意义，旨在提高我们对肠微孢子虫宿主特异性的理解及其对种间和人畜共患病传播的影响。
