Division of Urology, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, 11490, Taiwan.
Department of Surgery, Kaohsiung Armed Forces General Hospital, Kaohsiung, 80284, Taiwan.
Sci Rep. 2019 May 10;9(1):7240. doi: 10.1038/s41598-019-43746-x.
We aimed to explore the correlation between ketamine abuse and lower urinary tract symptoms (LUTS) and epidemiology of ketamine cystitis. Questionnaire records of ketamine abusers, such as sex, age, and details of using ketamine, including consumption method, amount, duration of ketamine use, and LUTS, were obtained from two private rehabilitation centers. We analyzed these factors and established a severity forecasting module. One hundred and six ketamine abusers completed the questionnaires. LUTS showed an onset time of 24.67 ± 26.36 months among ketamine abusers. Overactive bladder symptom score, international prostate symptom score-storage, interstitial cystitis symptom index, interstitial cystitis problem index, and visual analogue scale score were 5.25 ± 4.43, 5.95 ± 5.72, 10.96 ± 6.66, 9.73 ± 5.82, and 2.55 ± 3.18, respectively. All symptom scores were positively correlated with the duration of ketamine abuse. Ketamine snorting was significantly correlated with all symptom scores compared to smoking. Hydrodistention, intravesical hyaluronic acid instillation, intravesical injection with botulinum toxin, and hyperbaric-oxygen therapy showed better effect than oral treatment. Ketamine can induce severe storage symptoms, such as frequency or nocturia depending on the duration of abuse. Ketamine snorting may cause worse LUTS than smoking. Combining ketamine and other substances may exacerbate LUTS. Intravesical therapy may lead to better outcomes than oral treatment.
我们旨在探讨氯胺酮滥用与下尿路症状（LUTS）的相关性，以及氯胺酮性膀胱炎的流行病学。从两家私人康复中心获得了氯胺酮滥用者的问卷记录，如性别、年龄以及使用氯胺酮的详细信息，包括使用方式、用量、氯胺酮使用持续时间以及 LUTS。我们分析了这些因素并建立了严重程度预测模块。106 名氯胺酮滥用者完成了问卷。LUTS 在氯胺酮滥用者中的发病时间为 24.67±26.36 个月。膀胱过度活动症症状评分、国际前列腺症状评分-储存、间质性膀胱炎症状指数、间质性膀胱炎问题指数和视觉模拟评分分别为 5.25±4.43、5.95±5.72、10.96±6.66、9.73±5.82 和 2.55±3.18。所有症状评分均与氯胺酮滥用持续时间呈正相关。与吸烟相比，氯胺酮鼻吸与所有症状评分均显著相关。水扩张、膀胱内透明质酸灌注、膀胱内注射肉毒毒素和高压氧治疗的效果优于口服治疗。氯胺酮可引起严重的储存症状，如尿频或夜尿，具体取决于滥用的持续时间。氯胺酮鼻吸可能比吸烟引起更严重的 LUTS。合并使用氯胺酮和其他物质可能会加重 LUTS。膀胱内治疗可能比口服治疗效果更好。
