State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, P. R. China.
University of Science and Technology of China, Hefei, Anhui, 230029, P. R. China.
Angew Chem Int Ed Engl. 2019 Jul 15;58(29):9846-9850. doi: 10.1002/anie.201903981. Epub 2019 Jun 7.
The generation of singlet oxygen ( O ) during photodynamic therapy is limited by the precise cooperation of light, photosensitizer, and oxygen, and the therapeutic efficiency is restricted by the elevated glutathione (GSH) levels in cancer cells. Herein, we report that an ultrathin two-dimensional metal-organic framework of Cu-TCPP nanosheets (TCPP=tetrakis(4-carboxyphenyl)porphyrin) can selectively generate O in a tumor microenvironment. This process is based on the peroxidation of the TCPP ligand by acidic H O followed by reduction to peroxyl radicals under the action of the peroxidase-like nanosheets and Cu , and their spontaneous recombination reaction by the Russell mechanism. In addition, the nanosheets can also deplete GSH. Consequently, the Cu-TCPP nanosheets can selectively destroy tumor cells with high efficiency, constituting an attractive way to overcome current limitations of photodynamic therapy.
在光动力疗法中，单线态氧（O ）的产生受到光、光敏剂和氧气的精确配合的限制，治疗效率受到癌细胞中升高的谷胱甘肽（GSH）水平的限制。在此，我们报告一种超薄二维金属-有机骨架的 Cu-TCPP 纳米片（TCPP=四（4-羧基苯基）卟啉）可以在肿瘤微环境中选择性地产生 O 。这个过程是基于 TCPP 配体被酸性 H 2 O 2 过氧化，然后在过氧化物酶样纳米片和 Cu ²⁺ 的作用下还原为过氧自由基，并通过 Russell 机制自发进行重组反应。此外，纳米片还可以消耗 GSH。因此，Cu-TCPP 纳米片可以高效地选择性破坏肿瘤细胞，为克服光动力疗法的当前局限性提供了一种有吸引力的方法。
