Durham VA Health Care System, Durham, NC, USA; University of Toledo, Department of Psychology, Toledo, OH, USA.
Durham VA Health Care System, Durham, NC, USA; Research and Development Service, Durham Veterans Affairs Medical Center, Durham, NC, USA; Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA.
J Affect Disord. 2019 Jun 15;253:285-291. doi: 10.1016/j.jad.2019.04.035. Epub 2019 Apr 9.
Posttraumatic stress disorder (PTSD) and negative affect (e.g., anger, depression, anxiety), are highly co-occurring. It remains unclear whether changes in PTSD symptoms subsequently impact negative affect, or vice versa. This study assessed associations between moment-to-moment PTSD symptoms and negative affect in a sample of smokers with PTSD to determine directionality of this relationship.
Participants (N = 125) enrolled in two smoking cessation studies with co-occurring PTSD and cigarette use completed measures of PTSD and negative affect. Ecological momentary assessment (EMA) methodology was used to record symptoms during a one-week baseline period, during which participants smoked ad lib. Cross-lagged path analyses assessed PTSD symptoms and negative affect for directionality of their relationship, controlling for whether an EMA reading was smoking or non-smoking. Path analyses examined the lagged associations between PTSD symptoms and negative affect.
Results found PTSD symptom severity at T-1 was significantly related to negative affect levels at time T, but negative affect at time T-1 was not associated with PTSD symptom severity at time T. Results indicated the model retaining the cross-lagged effect of PTSD symptom severity on negative affect provided better fit to the data than other models.
Limitations included use of self-report data, brief measures of symptoms, participants already had PTSD and/or MDD, participants were recruited from a specific clinical population, and use of DSM-IV data.
Results suggest PTSD symptoms drive day-to-day fluctuations in negative affect, and highlight the importance of evaluating negative affect in the treatment of PTSD.
创伤后应激障碍(PTSD)和负性情绪(如愤怒、抑郁、焦虑)高度共病。目前尚不清楚 PTSD 症状的变化是否会随后影响负性情绪,或者反之亦然。本研究评估了 PTSD 症状与 PTSD 吸烟者样本中负性情绪之间的瞬间关联,以确定这种关系的方向。
参加同时存在 PTSD 和吸烟的两项戒烟研究的参与者(N=125)完成了 PTSD 和负性情绪的测量。使用生态瞬时评估(EMA)方法在一周的基线期内记录症状,在此期间,参与者自由吸烟。交叉滞后路径分析评估了 PTSD 症状和负性情绪之间的关系方向,控制 EMA 阅读是吸烟还是非吸烟。路径分析检验了 PTSD 症状和负性情绪之间的滞后关联。
结果发现 T-1 时的 PTSD 症状严重程度与 T 时的负性情绪水平显著相关,但 T-1 时的负性情绪与 T 时的 PTSD 症状严重程度无关。结果表明,保留 PTSD 症状严重度对负性情绪的交叉滞后效应的模型更符合数据。
限制包括使用自我报告数据、症状的简短测量、参与者已经患有 PTSD 和/或 MDD、参与者是从特定的临床人群中招募的,以及使用 DSM-IV 数据。
结果表明 PTSD 症状会导致负性情绪的日常波动,并强调在治疗 PTSD 时评估负性情绪的重要性。