Université de Lorraine, CNRS, IMoPA, F-54000, Nancy, France.
Université de Lorraine, CNRS, IMoPA, F-54000, Nancy, France.
Biochimie. 2019 Sep;164:17-21. doi: 10.1016/j.biochi.2019.05.006. Epub 2019 May 9.
Small nucleolar RNAs are generally involved in the modification of target ribosomal RNAs. Other possible functions recently emerged with the discovery of the novel class of snoRNA-derived RNAs or sdRNAs. Since then, additional data has revealed the involvement of both snoRNAs and sdRNAs in tumorigenesis. After briefly introducing snoRNA families and functions, this mini-review summarises recently acquired knowledge on snoRNA-related mechanisms associated with cancer. Despite the rapid increase in the number of studies, exactly how snoRNAs lead to cancer remains unclear. However, exciting new research is paving the way for future diagnostic or therapeutic strategies.
小核仁 RNA 通常参与靶核糖体 RNA 的修饰。随着新型 snoRNA 衍生 RNA 或 sdRNA 的发现，最近出现了其他可能的功能。此后，更多的数据表明 snoRNA 和 sdRNA 都参与了肿瘤发生。在简要介绍 snoRNA 家族和功能后，本综述总结了最近获得的与癌症相关的 snoRNA 相关机制的知识。尽管研究数量迅速增加，但 snoRNA 如何导致癌症仍不清楚。然而，令人兴奋的新研究为未来的诊断或治疗策略铺平了道路。
