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小核仁RNA：抗肿瘤治疗的潜在靶点。

SnoRNAs: The promising targets for anti-tumor therapy.

作者信息

Hu Xiaoyun, Cui Wanlin, Liu Min, Zhang Fangxiao, Zhao Yingqi, Zhang Mingrong, Yin Yuhang, Li Yalun, Che Ying, Zhu Xianglong, Fan Yuxuan, Deng Xiaolan, Wei Minjie, Wu Huizhe

机构信息

Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, 110122, China.

Liaoning Key Laboratory of Molecular Targeted Anti-tumor Drug Development and Evaluation, Liaoning Cancer Immune Peptide Drug Engineering Technology Research Center, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors, Ministry of Education, China Medical University, Shenyang, 110122, China.

出版信息

J Pharm Anal. 2024 Nov;14(11):101064. doi: 10.1016/j.jpha.2024.101064. Epub 2024 Aug 5.

DOI:10.1016/j.jpha.2024.101064
PMID:39634568
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11613181/
Abstract

Recently, small nucleolar RNAs (snoRNAs) have transcended the genomic "noise" to emerge as pivotal molecular markers due to their essential roles in tumor progression. Substantial evidence indicates a strong association between snoRNAs and critical clinical features such as tumor pathology and drug resistance. Historically, snoRNA research has concentrated on two classical mechanisms: 2'--ribose methylation and pseudouridylation. This review specifically summarizes the novel regulatory mechanisms and functional patterns of snoRNAs in tumors, encompassing transcriptional, post-transcriptional, and post-translational regulation. We further discuss the synergistic effect between snoRNA host genes (SNHGs) and snoRNAs in tumor progression. More importantly, snoRNAs extensively contribute to the development of tumor cell resistance as oncogenes or tumor suppressor genes. Accordingly, we provide a comprehensive review of the clinical diagnosis and treatment associated with snoRNAs and explore their significant potential as novel drug targets.

摘要

最近，小核仁RNA（snoRNAs）已超越基因组“噪音”，因其在肿瘤进展中的重要作用而成为关键的分子标志物。大量证据表明，snoRNAs与肿瘤病理学和耐药性等关键临床特征之间存在密切关联。从历史上看，snoRNA研究主要集中在两种经典机制：2'-核糖甲基化和假尿苷化。本综述特别总结了snoRNAs在肿瘤中的新型调控机制和功能模式，包括转录、转录后和翻译后调控。我们进一步讨论了snoRNA宿主基因（SNHGs）与snoRNAs在肿瘤进展中的协同作用。更重要的是，snoRNAs作为癌基因或肿瘤抑制基因广泛促进肿瘤细胞耐药性的发展。因此，我们对与snoRNAs相关的临床诊断和治疗进行了全面综述，并探讨了它们作为新型药物靶点的巨大潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5284/11613181/ac71925da1c8/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5284/11613181/24cb4003188d/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5284/11613181/faf35eada17c/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5284/11613181/fbc5dfc21866/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5284/11613181/3992a48358be/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5284/11613181/fcf9c3cb3997/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5284/11613181/db6b99522e12/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5284/11613181/ac71925da1c8/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5284/11613181/24cb4003188d/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5284/11613181/faf35eada17c/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5284/11613181/fbc5dfc21866/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5284/11613181/3992a48358be/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5284/11613181/fcf9c3cb3997/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5284/11613181/db6b99522e12/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5284/11613181/ac71925da1c8/gr6.jpg

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Oxidative stress affects the beginning of the growth of cancer cells through a variety of routes.
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Front Immunol. 2025 Apr 10;16:1572108. doi: 10.3389/fimmu.2025.1572108. eCollection 2025.
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GL4SDA: Predicting snoRNA-disease associations using GNNs and LLM embeddings.GL4SDA：使用图神经网络（GNNs）和语言模型（LLM）嵌入来预测小核仁RNA（snoRNA）与疾病的关联。
Comput Struct Biotechnol J. 2025 Mar 12;27:1023-1033. doi: 10.1016/j.csbj.2025.03.014. eCollection 2025.
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Non-Coding RNAs in Cancer: Structure, Function, and Clinical Application.癌症中的非编码RNA：结构、功能及临床应用
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