Division of Sport Science & Sport Science Institute, Incheon National University, Incheon, South Korea; Neuromechanical Rehabilitation Research Laboratory, Incheon National University, Incheon, South Korea.
Division of Sport Science & Sport Science Institute, Incheon National University, Incheon, South Korea; Neuromechanical Rehabilitation Research Laboratory, Incheon National University, Incheon, South Korea.
Addict Behav. 2019 Sep;96:133-139. doi: 10.1016/j.addbeh.2019.05.006. Epub 2019 May 6.
The purpose of this systematic review and meta-analysis was to investigate the effects of transcranial direct current stimulation (tDCS) on symptoms of nicotine dependence in treatment-seeking smokers. Twelve studies qualified for this meta-analysis, and we used 15 total comparisons from the included studies for the data synthesis. Primary outcome measures were changes in (a) cue-provoked craving and (b) smoking intake (i.e., the number of cigarettes smoked) between active tDCS stimulation and sham control groups. Random-effects model meta-analyses revealed significant positive effects of tDCS on seven cue-provoked craving comparisons (effect size = 0.422; P = .004) and eight smoking intake comparisons (effect size = 0.557; P = .004). Moderator variable analyses indicated that applying anodal-tDCS on the right dorsolateral prefrontal cortex (DLPFC) revealed significant positive effects on the cue-provoked craving with minimal heterogeneity. Further, applying cathodal-tDCS on DLPFC regions showed more positive effects on both cue-provoked craving and smoking intake than cathodal-tDCS on other brain regions. These findings suggested that tDCS modulating DLPFC activity can be an effective option for decreasing individual's smoking dependence symptoms.
本系统评价和荟萃分析的目的是研究经颅直流电刺激（tDCS）对有治疗需求的吸烟者尼古丁依赖症状的影响。有 12 项研究符合纳入标准，我们从纳入的研究中使用了 15 项总比较进行数据综合。主要结局指标是活跃 tDCS 刺激组与假刺激对照组之间（a）线索诱发的渴望和（b）吸烟摄入量（即吸烟的支数）的变化。随机效应模型荟萃分析显示，tDCS 对 7 项线索诱发的渴望比较有显著的积极影响（效应大小=0.422；P=0.004）和 8 项吸烟摄入比较有显著的积极影响（效应大小=0.557；P=0.004）。调节变量分析表明，在右侧背外侧前额叶皮质（DLPFC）施加阳极 tDCS 对线索诱发的渴望有显著的积极影响，异质性最小。此外，在 DLPFC 区域施加阴极 tDCS 比在其他脑区施加阴极 tDCS 对线索诱发的渴望和吸烟摄入都有更积极的影响。这些发现表明，调节 DLPFC 活动的 tDCS 可能是减少个体吸烟依赖症状的有效选择。
