Institute of Pharmacy and Chemistry, Dali University, Dali 671000, China; Department of Pharmacy, 920th Hospital of Joint Logistics Support Force, Kunming 650032, China.
Department of Infectious Diseases, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming 650000, China.
Gene. 2019 Jul 20;706:115-123. doi: 10.1016/j.gene.2019.05.025. Epub 2019 May 10.
UGT2B7 was recently acknowledged as a new critical enzyme involved in biotransformation of a variety of carcinogens, whose function was reported to be significantly associated with its encoding gene (UGT2B7) polymorphisms. However, results regarding the associations between single nucleotide polymorphisms (SNPs) of UGT2B7 and cancer risk still remained controversial. Therefore, a meta-analysis was conducted to further elucidate the role of UGT2B7 SNPs on cancer susceptibilities.
PubMed, EMBASE, Cochrane library, Chinese National Knowledge Infrastructure (CNKI), Technology of Chongqing (VIP) and Wan Fang Database were searched for eligible studies until March 2019. All analysis was carried out using the Review Manager 5.3 software. Subgroup analyses were performed by cancer types, ethnicity or source of controls.
13 studies with a total of 7688 cancer cases and 11,281 controls were included in this meta-analysis. The results showed that UGT2B7 rs7439366 increased the colorectal cancer risk in dominant model (OR = 0.76, 95% CI = 0.61-0.95, P = 0.02). However, as for the rs7435335 and rs12233719, we did not find their associations with cancer risk in all genetic models. In addition, the rs7441774 was found to be associated with breast cancer risk and significantly reduced papillary thyroid cancer risk in rs3924194 was also observed. Nevertheless, these findings remained to be further proven in future studies since these 2 SNPs were only respectively involved in 1 study.
This meta-analysis confirmed the association of UGT2B7 rs7439366 with colorectal cancer risk, which may be a potential promising biomarker for prediction of colorectal cancer risk.
UGT2B7 最近被认为是一种新的关键酶，参与多种致癌物的生物转化，其功能与编码基因（UGT2B7）多态性显著相关。然而，关于 UGT2B7 单核苷酸多态性（SNPs）与癌症风险之间的关联结果仍存在争议。因此，进行了一项荟萃分析，以进一步阐明 UGT2B7 SNPs 对癌症易感性的作用。
检索 PubMed、EMBASE、Cochrane 图书馆、中国国家知识基础设施（CNKI）、重庆维普（VIP）和万方数据库，以获取符合条件的研究，截至 2019 年 3 月。所有分析均使用 Review Manager 5.3 软件进行。按癌症类型、种族或对照来源进行亚组分析。
本荟萃分析共纳入 13 项研究，共计 7688 例癌症病例和 11281 例对照。结果表明，UGT2B7 rs7439366 增加了结肠癌的风险，在显性模型中（OR=0.76，95%CI=0.61-0.95，P=0.02）。然而，对于 rs7435335 和 rs12233719，我们没有发现它们与所有遗传模型中的癌症风险相关。此外，还发现 rs7441774 与乳腺癌风险相关，rs3924194 与甲状腺乳头状癌风险显著降低相关。然而，由于这两个 SNP 分别仅涉及 1 项研究，因此这些发现仍需要进一步的研究证实。
本荟萃分析证实了 UGT2B7 rs7439366 与结直肠癌风险的相关性，这可能是预测结直肠癌风险的一个有前途的潜在生物标志物。
