Mitochondrial Function, Mobility and Lifespan Are Improved in by Extracts of 9--β-Carotene from .

Carotenoids are implicated in alleviating ageing and age-related diseases in humans. While data from different carotenoids are mixed in their outcomes, those for 9--β-carotene indicate general positive effects, although basic data on its biological impact are limited. Here, we show that supplementation with 9--β-carotene in ageing improved mitochondrial function in terms of ATP production and whole-body respiration and extended mean lifespan. It also resulted in improved mobility. These data provide a potential biological rational for the beneficial effects of dietary supplementation with 9-β-carotene. These effects may be based on the maintenance of a sound mitochondrial function.