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1
Development of fetal thymocytes in organ cultures. Effect of interleukin 2.器官培养中胎儿胸腺细胞的发育。白细胞介素2的作用。
J Exp Med. 1987 Jun 1;165(6):1481-93. doi: 10.1084/jem.165.6.1481.
2
Differentiation of thymocytes in fetal organ culture: analysis of phenotypic changes accompanying the appearance of cytolytic and interleukin 2-producing cells.胎儿器官培养中胸腺细胞的分化：伴随溶细胞性细胞和白细胞介素2产生细胞出现的表型变化分析。
J Immunol. 1984 Sep;133(3):1117-23.
3
Effect of interleukin 2 on fetal thymocytes in organ cultures: generation of lymphokine-activated killer cells.白细胞介素2对器官培养中胎儿胸腺细胞的影响：淋巴因子激活的杀伤细胞的产生。
Cell Immunol. 1988 Mar;112(1):104-11. doi: 10.1016/0008-8749(88)90279-1.
4
Exogenous IL-7 promotes the growth of CD3-CD4-CD8-CD44+CD25+/- precursor cells and blocks the differentiation pathway of TCR-alpha beta cells in fetal thymus organ culture.外源性白细胞介素-7促进胎儿胸腺器官培养中CD3-CD4-CD8-CD44+CD25+/-前体细胞的生长，并阻断TCR-αβ细胞的分化途径。
J Immunol. 1993 Apr 1;150(7):2706-16.
5
Qualitative and quantitative heterogeneity in Pgp-1 expression among murine thymocytes.小鼠胸腺细胞中Pgp-1表达的定性和定量异质性。
Cell Immunol. 1988 Mar;112(1):40-54. doi: 10.1016/0008-8749(88)90274-2.
6
Thymocyte subpopulations during early fetal development in the BALB/c mouse.BALB/c小鼠早期胎儿发育过程中的胸腺细胞亚群。
J Immunol. 1988 Aug 1;141(3):736-40.
7
Developmentally controlled expression of IL 2 receptors and of sensitivity to IL 2 in a subset of embryonic thymocytes.胚胎胸腺细胞亚群中白细胞介素2受体的发育调控表达及对白细胞介素2的敏感性
J Immunol. 1985 Jun;134(6):3891-4.
8
Absence of growth by most receptor-expressing fetal thymocytes in the presence of interleukin-2.在白细胞介素-2存在的情况下，大多数表达受体的胎儿胸腺细胞缺乏生长。
Nature. 1985;314(6011):539-40. doi: 10.1038/314539a0.
9
Proliferation in vitro and interleukin production by 14 day fetal and adult Lyt-2-/L3T4- mouse thymocytes.14日龄胎儿及成年Lyt-2-/L3T4-小鼠胸腺细胞的体外增殖及白细胞介素产生
J Immunol. 1986 Oct 1;137(7):2260-7.
10
Subpopulations of early thymocytes. A cross-correlation flow cytometric analysis of adult mouse Ly-2-L3T4-(CD8-CD4-) thymocytes using eight different surface markers.早期胸腺细胞亚群。使用八种不同表面标志物对成年小鼠Ly-2-L3T4-（CD8-CD4-）胸腺细胞进行交叉相关流式细胞术分析。
J Immunol. 1988 Mar 1;140(5):1461-9.

引用本文的文献

1
The serum factor from patients with ulcerative colitis that induces T cell proliferation in the mouse thymus is interleukin-7.溃疡性结肠炎患者血清中能诱导小鼠胸腺T细胞增殖的因子是白细胞介素-7。
J Clin Immunol. 1997 Jul;17(4):282-92. doi: 10.1023/a:1027322631036.
2
Prolactin increases CD4/CD8 cell ratio in thymus-grafted congenitally athymic nude mice.催乳素可提高胸腺移植的先天性无胸腺裸鼠的CD4/CD8细胞比率。
Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):4165-9. doi: 10.1073/pnas.93.9.4165.
3
T cell receptor ligation induces interleukin (IL) 2R beta chain expression in rat CD4,8 double positive thymocytes, initiating an IL-2-dependent differentiation pathway of CD8 alpha+/beta- T cells.T细胞受体连接可诱导大鼠CD4、8双阳性胸腺细胞中白细胞介素（IL）-2受体β链的表达，启动CD8α+/β-T细胞的IL-2依赖性分化途径。
J Exp Med. 1993 Feb 1;177(2):541-6. doi: 10.1084/jem.177.2.541.
4
Phenotypic analysis of mouse thymus development.小鼠胸腺发育的表型分析。
Immunol Res. 1988;7(4):265-78. doi: 10.1007/BF02935532.
5
IL-3 and IL-4 affect thymocyte differentiation in organ culture.白细胞介素-3和白细胞介素-4影响器官培养中的胸腺细胞分化。
Immunology. 1990 Sep;71(1):83-9.

本文引用的文献

1
Effects of cytotoxic monoclonal antibody specific for T200 glycoprotein on functional lymphoid cell populations.针对T200糖蛋白的细胞毒性单克隆抗体对功能性淋巴细胞群体的影响。
Cell Immunol. 1980 Aug 1;53(2):350-64. doi: 10.1016/0008-8749(80)90335-4.
2
Interleukin-2 dependent culture of cytolytic T cell lines.细胞溶解性T细胞系的白细胞介素-2依赖性培养
Immunol Rev. 1981;54:81-109. doi: 10.1111/j.1600-065x.1981.tb00435.x.
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T-cell growth factor.T细胞生长因子。
Immunol Rev. 1980;51:337-57. doi: 10.1111/j.1600-065x.1980.tb00327.x.
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Development of cytolytic T lymphocyte precursors in organ-cultured mouse embryonic thymus rudiments.器官培养的小鼠胚胎胸腺原基中细胞溶解性T淋巴细胞前体的发育
J Exp Med. 1982 Feb 1;155(2):617-22. doi: 10.1084/jem.155.2.617.
5
Differentiation of thymocytes in fetal organ culture: analysis of phenotypic changes accompanying the appearance of cytolytic and interleukin 2-producing cells.胎儿器官培养中胸腺细胞的分化：伴随溶细胞性细胞和白细胞介素2产生细胞出现的表型变化分析。
J Immunol. 1984 Sep;133(3):1117-23.
6
In-vivo modulation of thymus-derived lymphocytes with monoclonal antibodies in mice. I. Effect of anti-Thy-1 antibody on the tissue distribution of lymphocytes.小鼠体内用单克隆抗体对胸腺来源淋巴细胞的调节。I. 抗Thy-1抗体对淋巴细胞组织分布的影响。
Immunology. 1983 Dec;50(4):537-46.
7
The enhancement of cultured spontaneous cytotoxic T cells from normal and athymic (nu/nu) mice.来自正常和无胸腺（裸鼠，nu/nu）小鼠的培养自发细胞毒性T细胞的增强。
Aust J Exp Biol Med Sci. 1983 Aug;61 (Pt 4):461-70. doi: 10.1038/icb.1983.43.
8
Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 molecule.用单克隆抗体GK1.5鉴定的小鼠T细胞表面分子L3T4的特性：L3T4与人Leu-3/T4分子的相似性
J Immunol. 1983 Nov;131(5):2445-51.
9
Identification and initial characterization of a rat monoclonal antibody reactive with the murine interleukin 2 receptor-ligand complex.一种与小鼠白细胞介素2受体-配体复合物反应的大鼠单克隆抗体的鉴定及初步表征。
Proc Natl Acad Sci U S A. 1983 Sep;80(18):5694-8. doi: 10.1073/pnas.80.18.5694.
10
An NK-like cell limits the adoptive response from "pre-progenitor" B cells.一种自然杀伤样细胞限制了“前祖细胞”B细胞的过继性反应。
Aust J Exp Biol Med Sci. 1982 Dec;60(6):581-92. doi: 10.1038/icb.1982.61.

器官培养中胎儿胸腺细胞的发育。白细胞介素2的作用。

Development of fetal thymocytes in organ cultures. Effect of interleukin 2.

作者信息

Skinner M, Le Gros G, Marbrook J, Watson J D

出版信息

J Exp Med. 1987 Jun 1;165(6):1481-93. doi: 10.1084/jem.165.6.1481.

DOI:10.1084/jem.165.6.1481
PMID:3108443
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2188371/
Abstract

Most fetal thymocytes from 14-d mouse embryos are Thy-1+, L3T4-, Ly-2-, and express the receptor for interleukin 2 (IL-2). The development of thymocytes has been followed in fetal thymus organ cultures. When fetal thymus from 14-d embryos were cultured for a 6-d period, thymocytes increased in number 20-40-fold, and 95% became Thy-1+, L3T4+, Ly-2+. The addition of IL-2 to organ cultures of 14-d fetal thymus inhibited, in a dose-dependent manner, cell proliferation and the appearance of Thy-1+, L3T4+, Ly-2+ thymocytes. The addition of IL-2 also resulted in the appearance of a population of cells that were cytotoxic for syngeneic and allogeneic fetal thymocytes and syngeneic tumour targets. While the events that lead to the expression of the IL-2 receptor on 14-d fetal thymocytes are unknown, IL-2 in fetal thymus organ cultures inhibits the normal maturation of fetal thymocytes and raises the question of whether the cytotoxic cells that appear reflect selection through an alternative pathway of development.

摘要

来自14天龄小鼠胚胎的大多数胎儿胸腺细胞为Thy-1阳性、L3T4阴性、Ly-2阴性，并表达白细胞介素2（IL-2）受体。胸腺细胞的发育过程已在胎儿胸腺器官培养物中进行了跟踪研究。当将14天龄胚胎的胎儿胸腺培养6天时，胸腺细胞数量增加了20至40倍，且95%变为Thy-1阳性、L3T4阳性、Ly-2阳性。向14天龄胎儿胸腺的器官培养物中添加IL-2，以剂量依赖的方式抑制细胞增殖以及Thy-1阳性、L3T4阳性、Ly-2阳性胸腺细胞的出现。添加IL-2还导致出现了一群对同基因和异基因胎儿胸腺细胞以及同基因肿瘤靶标具有细胞毒性的细胞。虽然导致14天龄胎儿胸腺细胞表达IL-2受体的事件尚不清楚，但胎儿胸腺器官培养物中的IL-2会抑制胎儿胸腺细胞的正常成熟，并引发这样一个问题，即出现的细胞毒性细胞是否反映了通过另一种发育途径进行的选择。