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血管内超声评估的高内膜瓣活动度与慢性主动脉夹层 TEVAR 后的短期结果更好相关。

High intimal flap mobility assessed by intravascular ultrasound is associated with better short-term results after TEVAR in chronic aortic dissection.

机构信息

Department of Cardiology and Vascular Medicine, West- German Heart and Vascular Center Essen, University of Duisburg-Essen, Essen, Germany.

Department of Thoracic and Cardiovascular Surgery, West- German Heart and Vascular Center Essen, University of Duisburg-Essen, Essen, Germany.

出版信息

Sci Rep. 2019 May 13;9(1):7267. doi: 10.1038/s41598-019-43856-6.

Abstract

Thoracic endovascular aortic repair (TEVAR) in chronic aortic dissection remains controversial. We analysed whether a high intimal flap mobility (IFM) of the dissection membrane has an impact on aortic remodelling after TEVAR in chronic Type B aortic dissection. Patients undergoing TEVAR with intravascular ultrasound (IVUS) were analysed and IFM was calculated. High IFM was defined as maximum flap amplitude >3 mm. For determining aortic remodelling, the degree of true lumen (TL) expansion was analysed in the last available follow-up CT. Fifty-two patients (63.6 ± 15.4 years) with a mean follow-up of 26.6 ± 20.7 months were analysed. The mobile flap group (n = 29) showed higher absolute TL expansion at the distal stent-graft (5.9 ± 3.1 vs. 3.3 ± 5.4 mm; p = 0.036) and a higher increase in TL diameter (18 ± 10 vs. 9 ± 15%; p = 0.017) compared to the non-mobile group (n = 23). Basic TEVAR-related outcome characteristics were comparable, but the mobile intimal flap group showed a lower re-intervention rate (3 vs. 8pts.; p = 0.032) in chronic dissections. High IFM in chronic Type B aortic dissection is linked to improved aortic remodelling and is associated with a lower re-intervention rate over time. IVUS assessment of IFM in chronic Type B aortic dissection might be helpful in identifying patients with better remodelling after TEVAR.

摘要

胸主动脉腔内修复术(TEVAR)治疗慢性主动脉夹层仍存在争议。我们分析了慢性 B 型主动脉夹层患者中,夹层膜内膜瓣活动度(IFM)是否对 TEVAR 后主动脉重塑有影响。对接受血管内超声(IVUS)检查并进行 TEVAR 的患者进行分析,并计算 IFM。高 IFM 定义为最大瓣振幅>3mm。为了确定主动脉重塑,在最后一次可获得的 CT 随访中分析真腔(TL)扩张程度。分析了 52 例(63.6±15.4 岁)患者的资料,平均随访 26.6±20.7 个月。在移动瓣组(n=29)中,远端支架移植物的 TL 扩张绝对值更高(5.9±3.1 vs. 3.3±5.4mm;p=0.036),TL 直径增加率更高(18±10 vs. 9±15%;p=0.017)。与非移动瓣组(n=23)相比,基础 TEVAR 相关结局特征相当,但移动瓣组慢性夹层的再介入率较低(3 例 vs. 8 例;p=0.032)。慢性 B 型主动脉夹层中 IFM 较高与主动脉重塑改善相关,并随时间推移与再介入率降低相关。慢性 B 型主动脉夹层中 IVUS 评估 IFM 可能有助于识别 TEVAR 后重塑更好的患者。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/819f/6513991/d49ee0badfec/41598_2019_43856_Fig1_HTML.jpg

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