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肿瘤治疗电场（TTFields）：有丝分裂末期/胞质分裂期细胞经电磁辐射作用的作用机制研究。

Tumour-treating fields (TTFields): Investigations on the mechanism of action by electromagnetic exposure of cells in telophase/cytokinesis.

机构信息

Institute of Microwave and Wireless Systems, Leibniz University Hannover, Hannover, Germany.

Institute of Cell Biology and Biophysics, Department of Cell Physiology and Biophysics, Leibniz University Hannover, Hannover, Germany.

出版信息

Sci Rep. 2019 May 14;9(1):7362. doi: 10.1038/s41598-019-43621-9.

DOI:10.1038/s41598-019-43621-9
PMID:31089145
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6517379/
Abstract

Tumour-treating fields (TTFields) use alternating electric fields which interfere with dividing cells, thereby reducing tumour growth. Previous reports suggest that electrical forces on cell structure proteins interfered with the chromosome separation during mitosis and induced apoptosis. In the present report we evaluate electromagnetic exposure of cells in telophase/cytokinesis in order to further analyse the mechanism of action on cells. We performed numerical electromagnetic simulations to analyse the field distribution in a cell during different mitotic phases. Based thereon, we developed an electric lumped element model of the mitotic cell. Both the electromagnetic simulation and the lumped element model predict a local increase of the specific absorption rate (SAR) as a measure of the electromagnetically induced power absorption density at the mitotic furrow which may help to explain the anti-proliferative effect. In accordance with other reports, cell culture experiments confirmed that TTFields reduce the proliferation of different glioma cell lines in a field strength- and frequency-dependent manner. Furthermore, we found an additional dependence on the commutation time of the electrical fields. The report gives new insights into TTFields' anti-proliferative effect on tumours, which could help to improve future TTFields application systems.

摘要

肿瘤治疗电场（TTFields）采用交变电场干扰分裂细胞，从而抑制肿瘤生长。先前的报告表明，细胞结构蛋白上的电力会干扰有丝分裂过程中的染色体分离，并诱导细胞凋亡。在本报告中，我们评估了细胞在末期/胞质分裂时的电磁场暴露情况，以便进一步分析对细胞的作用机制。我们进行了数值电磁场模拟，以分析细胞在不同有丝分裂阶段的场分布。在此基础上，我们开发了有丝分裂细胞的集总元件模型。电磁场模拟和集总元件模型都预测了在有丝分裂沟处的比吸收率（SAR）局部增加，这可以作为电磁感应功率吸收密度的指标，有助于解释其抑制增殖的作用。与其他报告一致的是，细胞培养实验证实 TTFields 以场强和频率依赖的方式降低了不同神经胶质瘤细胞系的增殖。此外，我们还发现其与电场的换向时间有关。本报告为 TTFields 对肿瘤的抗增殖作用提供了新的见解，这有助于改进未来 TTFields 应用系统。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/862b/6517379/c3926fa99651/41598_2019_43621_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/862b/6517379/1479d2420846/41598_2019_43621_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/862b/6517379/d41b743e9b6a/41598_2019_43621_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/862b/6517379/2c72f89869e6/41598_2019_43621_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/862b/6517379/eb2fd364cb15/41598_2019_43621_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/862b/6517379/b91b51282a5b/41598_2019_43621_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/862b/6517379/d72a42f8b8a7/41598_2019_43621_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/862b/6517379/e2f56812a84b/41598_2019_43621_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/862b/6517379/4d450074d272/41598_2019_43621_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/862b/6517379/12682f513232/41598_2019_43621_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/862b/6517379/c3926fa99651/41598_2019_43621_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/862b/6517379/1479d2420846/41598_2019_43621_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/862b/6517379/d41b743e9b6a/41598_2019_43621_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/862b/6517379/2c72f89869e6/41598_2019_43621_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/862b/6517379/eb2fd364cb15/41598_2019_43621_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/862b/6517379/b91b51282a5b/41598_2019_43621_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/862b/6517379/d72a42f8b8a7/41598_2019_43621_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/862b/6517379/e2f56812a84b/41598_2019_43621_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/862b/6517379/4d450074d272/41598_2019_43621_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/862b/6517379/12682f513232/41598_2019_43621_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/862b/6517379/c3926fa99651/41598_2019_43621_Fig10_HTML.jpg

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