淋巴细胞与单核细胞比值对行根治性膀胱切除术的膀胱癌患者预后的意义：5638 例个体的荟萃分析。

Prognostic Significance of the Lymphocyte-to-Monocyte Ratio in Bladder Cancer Undergoing Radical Cystectomy: A Meta-Analysis of 5638 Individuals.

机构信息

Department of Breast Surgery, Thyroid Surgery, Huangshi Central Hospital of Edong Healthcare Group, Hubei Polytechnic University, No. 141, Tianjin Road, Huangshi, Hubei, China.

出版信息

Dis Markers. 2019 Apr 4;2019:7593560. doi: 10.1155/2019/7593560. eCollection 2019.

INTRODUCTION

A growing number of studies have explored the association between the pretreatment lymphocyte-to-monocyte ratio (LMR) and survival outcomes in various cancers. However, its prognostic significance on bladder cancer remains inconsistent. The aim of this meta-analysis was to evaluate the prognostic value of pretreatment LMR in bladder cancer.

METHODS

The MEDLINE, EMBASE, Cochrane Library, and CNKI databases were comprehensively searched for relevant studies. A meta-analysis of overall survival (OS), recurrence-free survival (RFS), or cancer-specific survival (CSS) clinicopathological features was conducted.

RESULTS

Nine studies containing 5,638 cancer patients were analyzed in this meta-analysis. Patients with high LMR tended to have favourable OS (HR: 0.63, 95% CI: 0.50-0.80, < 0.001), RFS (HR: 0.59, 95% CI: 0.38-0.91, = 0.017), and CSS (HR: 0.76, 95% CI: 0.70-0.83, < 0.001). Moreover, low LMR was highly correlated with age (≥60), differentiation (low), T stage (III-IV), lymph node metastasis (yes), and concomitant Cis (yes).

CONCLUSION

Pretreatment LMR might be a useful predictor of survival outcomes in patients with bladder cancer.

简介

越来越多的研究探讨了预处理淋巴细胞与单核细胞比值（LMR）与各种癌症生存结局之间的关系。然而，其在膀胱癌中的预后意义尚不一致。本荟萃分析旨在评估预处理 LMR 在膀胱癌中的预后价值。

方法

全面检索 MEDLINE、EMBASE、Cochrane 图书馆和中国知网数据库中相关研究。对总生存（OS）、无复发生存（RFS）或癌症特异性生存（CSS）的临床病理特征进行荟萃分析。

结果

本荟萃分析纳入了 9 项包含 5638 例癌症患者的研究。高 LMR 患者的 OS（HR：0.63，95%CI：0.50-0.80，<0.001）、RFS（HR：0.59，95%CI：0.38-0.91，=0.017）和 CSS（HR：0.76，95%CI：0.70-0.83，<0.001）均较好。此外，低 LMR 与年龄（≥60 岁）、分化（低）、T 分期（III-IV 期）、淋巴结转移（阳性）和同时合并 Cis（阳性）高度相关。