Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China.
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
Oxid Med Cell Longev. 2019 Mar 18;2019:5172480. doi: 10.1155/2019/5172480. eCollection 2019.
decoction (BYD), a traditional representative formula, has a long usage history in the treatment of cardiovascular diseases. Since the hyperlipidemia-induced dysfunction of erythrocyte is one of the most important causes of cardiovascular diseases, the improving effects of BYD against high-fat diet (HFD) induced the physiological and physical function of the erythrocytic injury and the potential mechanisms were deeply researched in this study. After 6 weeks of drug treatment, all doses of BYD had significantly decreased the lipid peroxidation in plasma of HFD-induced ApoE mice, even if it had not improved the lipid levels. Then, the erythrocyte-related experimental results showed that BYD had reduced erythrocyte osmotic fragility, stabilized erythrocyte membrane skeleton protein 4.2, and reformed the erythrocyte morphological changes by decreasing erythrocyte membrane lipid peroxidation levels. This study demonstrated that BYD may ameliorate the physiological and physical function of erythrocyte in hyperlipidemic mice through the antioxidant effect on erythrocyte membranes.
方剂（BYD）是一种传统的代表性配方，在治疗心血管疾病方面有着悠久的使用历史。由于高脂血症引起的红细胞功能障碍是心血管疾病最重要的原因之一，因此本研究深入研究了 BYD 对高脂肪饮食（HFD）诱导的红细胞损伤的生理和物理功能的改善作用及其潜在机制。经过 6 周的药物治疗，BYD 的所有剂量均显著降低了 HFD 诱导的 ApoE 小鼠血浆中的脂质过氧化水平，即使它没有改善血脂水平。然后，红细胞相关的实验结果表明，BYD 降低了红细胞渗透脆性，稳定了红细胞膜骨架蛋白 4.2，并通过降低红细胞膜脂质过氧化水平来改变红细胞的形态变化。本研究表明，BYD 可能通过抗氧化作用改善高脂血症小鼠的红细胞生理和物理功能。
