School of Food Science and Engineering, South China University of Technology, 381 Wushan Road, Guangzhou 510640, Guangdong, China.
Food Funct. 2019 Jun 19;10(6):3224-3236. doi: 10.1039/c9fo00263d.
This study aimed to evaluate the regulation of lipid metabolism and mechanism of a sulfated polysaccharide from Gracilaria Lemaneiformis (GLP). The results showed that GLP significantly decreased the hepatic total cholesterol (TC) and triglyceride (TG) levels in the serum of high-fat diet mice and prevented body weight gain and alleviated the accumulation of fat. Furthermore, GLP may accelerate the conversion of cholesterol to bile acids by promoting the expression of LxRα and CYP7A1 genes and regulating the relative abundance of Bacteroides, Ruminococcus_1 and Lactobacillus. Pearson's correlation analysis showed that the relative abundance of Alistipes, Prevotellaceae_UCG-001, and Corprococcus_1 was negatively associated with the hydrophobic BAs CDCA and DCA levels, while the relative abundance of Lachnospiraceae_NK4A136_group and Roseburia was positively correlated with the hydrophilic BAs UDCA and TUDCA levels. This study suggests that GLP can be used as a functional food for regulating cholesterol metabolism.
本研究旨在评估来自江蓠（Gracilaria Lemaneiformis）的硫酸多糖(GLP)对脂代谢的调节作用及其机制。结果表明，GLP 可显著降低高脂饮食小鼠血清中的总胆固醇(TC)和甘油三酯(TG)水平，防止体重增加，并减轻脂肪堆积。此外，GLP 可能通过促进 LxRα 和 CYP7A1 基因的表达以及调节拟杆菌、瘤胃球菌_1 和乳杆菌的相对丰度来加速胆固醇向胆汁酸的转化。Pearson 相关性分析表明，Alistipes、Prevotellaceae_UCG-001 和 Corprococcus_1 的相对丰度与疏水性胆汁酸 CDCA 和 DCA 水平呈负相关，而 Lachnospiraceae_NK4A136_group 和 Roseburia 的相对丰度与亲水性胆汁酸 UDCA 和 TUDCA 水平呈正相关。本研究表明，GLP 可作为一种调节胆固醇代谢的功能性食品。
