Park Hye-Jung, Kim Ji-Youn, Kim Hee Sook, Lee Sang-Hyeon, Jang Jeong Su, Lee Mun Hyon
Food Research Center, Angel Co., Ltd., Busan, 46988 Korea.
2Major in Pharmaceutical Engineering, Division of Bioindustry, College of Medical and Life Sciences, Silla University, Busan, 46958 Korea.
Food Sci Biotechnol. 2018 Nov 23;28(3):881-893. doi: 10.1007/s10068-018-0512-0. eCollection 2019 Jun.
Commonly consumed fruit juices possess low inhibitory activity of angiotensin I-converting enzyme (ACE), which plays central role in elevation of blood pressure. The ACE inhibitory activity of fruit-seed mixed juice may be improved via synergistic interactions. In this study, the investigated synergistic, additive, and antagonistic effects of fruit-seed combination on ACE inhibition were investigated. Thirteen fruits and 15 seeds including legumes, nuts, and cereals were combined in pairs; pear-hemp seed-pumpkin seed juice (3-mixed juice) displayed the highest ACE inhibition resulting from synergistic interactions. Additionally, nitric oxide production in human endothelial cells was promoted by 3-mixed juice. Three-mixed juice showed antioxidant activities such as DNA protective, DPPH radical scavenging, and reducing effects. These results suggested that combinations of different food categories are beneficial for improving biological functions such as vascular health. Three-mixed juice, which shows high ACE inhibitory activity, may be useful as an anti-hypertensive agent and for treating hypertension.
常见的食用果汁对血管紧张素转换酶（ACE）的抑制活性较低，而ACE在血压升高过程中起核心作用。通过协同相互作用，可提高果籽混合汁的ACE抑制活性。在本研究中，研究了果籽组合对ACE抑制的协同、相加和拮抗作用。将13种水果和15种种子（包括豆类、坚果和谷物）两两组合；梨-麻籽-南瓜籽汁（三混合汁）因协同相互作用而表现出最高的ACE抑制率。此外，三混合汁可促进人内皮细胞中一氧化氮的产生。三混合汁具有DNA保护、清除DPPH自由基和还原作用等抗氧化活性。这些结果表明，不同食物种类的组合有利于改善血管健康等生物学功能。具有高ACE抑制活性的三混合汁可能作为抗高血压药物用于治疗高血压。
