Kim Hyuk Hwa, Kang Yu-Ri, Choi Hwang-Yong, Lee Jung-Yun, Oh Jung-Bae, Kim Justin S, Kim Young-Cheul, Lee Ki Won, Kwon Young-In
1Department of Agricultural Biotechnology, Seoul National University, Seoul, Korea.
2Department of Food and Nutrition, Hannam University, Daejeon, Korea.
Food Sci Biotechnol. 2019 Jan 4;28(3):907-911. doi: 10.1007/s10068-018-0534-7. eCollection 2019 Jun.
Postprandial blood glucose lowering effect of vitamin B (pyridoxine) was evaluated in healthy individuals with normal blood glucose levels. Blood glucose levels were measured every 30 min for 2 h after oral sugar administration with or without 50 mg of pyridoxine. Pyridoxine significantly lowered the postprandial blood glucose levels at 30 min (from 165.95 ± 17.19 to 138.36 ± 20.43, < 0.01) and 60 min (from 131.40 ± 17.20 to 118.50 ± 15.95) after administration. In addition, the area under the concentration-time curve (AUC) was reduced by about 8.3% (from 257.08 ± 22.38 to 235.71 ± 12.33, < 0.05) and the maximum concentration of blood glucose (C) was reduced by about 13.8% (from 165.95 ± 17.19 to 143.07 ± 11.34, < 0.01) when compared with those of the control group. Our findings suggest that pyridoxine supplementation may be beneficial for controlling postprandial hyperglycemia.
在血糖水平正常的健康个体中评估了维生素B（吡哆醇）的餐后降血糖作用。在口服糖（加或不加50mg吡哆醇）后2小时内，每30分钟测量一次血糖水平。吡哆醇在给药后30分钟（从165.95±17.19降至138.36±20.43，P<0.01）和60分钟（从131.40±17.20降至118.50±15.95）时显著降低了餐后血糖水平。此外，与对照组相比，浓度-时间曲线下面积（AUC）降低了约8.3%（从257.08±22.38降至235.71±12.33，P<0.05），血糖最大浓度（C）降低了约13.8%（从165.95±17.19降至143.07±11.34，P<0.01）。我们的研究结果表明，补充吡哆醇可能有助于控制餐后高血糖。
