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本文引用的文献

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Molecular weight dependent glucose lowering effect of low molecular weight Chitosan Oligosaccharide (GO2KA1) on postprandial blood glucose level in SD rats model.低分子量壳寡糖（GO2KA1）对SD大鼠模型餐后血糖水平的降血糖作用及其分子量依赖性
Int J Mol Sci. 2013 Jul 9;14(7):14214-24. doi: 10.3390/ijms140714214.
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α-Glucosidase inhibitors and their use in clinical practice.α-葡萄糖苷酶抑制剂及其在临床实践中的应用。
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Prediabetes: a high-risk state for diabetes development.糖尿病前期：糖尿病发展的高危状态。
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Projection of the year 2050 burden of diabetes in the US adult population: dynamic modeling of incidence, mortality, and prediabetes prevalence.2050 年美国成年人口糖尿病负担预测：发病率、死亡率和糖尿病前期患病率的动态建模。
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Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes.2 型糖尿病患者高血糖的医学管理：起始和调整治疗的共识算法：美国糖尿病协会和欧洲糖尿病研究协会的共识声明。
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Antidiabetic effects of chitosan oligosaccharides in neonatal streptozotocin-induced noninsulin-dependent diabetes mellitus in rats.壳寡糖对新生大鼠链脲佐菌素诱导的非胰岛素依赖型糖尿病的抗糖尿病作用。
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低分子量壳寡糖GO2KA1对健康个体食用面包后餐后血糖水平的影响。

Effect of supplementation of low-molecular-weight chitosan oligosaccharide, GO2KA1, on postprandial blood glucose levels in healthy individuals following bread consumption.

作者信息

Kang Yu-Ri, Choi Hwang-Yong, Lee Jung-Yun, Jang Soo-In, Oh Jung-Bae, Kim Justin S, Lee Jong-Wook, Jo Sung-Hoon, Ha Kyoung-Soo, Lee Mee-Sook, Kim Young-Cheul, Apostolidis Emmanouil, Kwon Young-In

机构信息

4Department of Food and Nutrition, Hannam University, Daejeon, 34054 Korea.

1Department of Nutrition, University of Massachusetts, Amherst, MA 01003 USA.

出版信息

Food Sci Biotechnol. 2016 Jun 30;25(3):911-914. doi: 10.1007/s10068-016-0149-9. eCollection 2016.

DOI:10.1007/s10068-016-0149-9
PMID:30263353
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6049137/
Abstract

The effect of chitosan oligosaccharide (GO2KA1) administration on postprandial blood glucose levels of subjects with normal blood glucose levels was evaluated following bread consumption. Postprandial blood glucose levels were determined for 2 h after bread ingestion with or without 500 mg of GO2KA1. GO2KA1 significantly lowered the mean, maximum, and minimum levels of postprandial blood glucose at 30 min after the meal. Postprandial blood glucose levels were decreased by about 25% (from 155.11±13.06 to 138.50±13.59, <0.01) at 30 min when compared to control. Furthermore, we observed that the area under the concentration-time curve (AUCt) was decreased by about 6% (from 255.46±15.43 to 240.15±14.22, <0.05) and the peak concentration of blood glucose ( ) was decreased by about 11% (from 157.94±10.90 to 140.61±12.52, <0.01) when compared to control. However, postprandial the time to reach (T) levels were the same as those found in control. Our findings suggest that GO2KA1 limits the increase in postprandial blood glucose levels following bread consumption.

摘要

在食用面包后，评估了壳寡糖（GO2KA1）给药对血糖水平正常受试者餐后血糖水平的影响。在摄入含有或不含有500mg GO2KA1的面包后，测定2小时的餐后血糖水平。GO2KA1显著降低了餐后30分钟时餐后血糖的平均、最高和最低水平。与对照组相比，餐后30分钟时餐后血糖水平降低了约25%（从155.11±13.06降至138.50±13.59，<0.01）。此外，我们观察到，与对照组相比，浓度-时间曲线下面积（AUCt）降低了约6%（从255.46±15.43降至240.15±14.22，<0.05），血糖峰值浓度（ ）降低了约11%（从157.94±10.90降至140.61±12.52，<0.01）。然而，餐后达到 （T）水平的时间与对照组相同。我们的研究结果表明，GO2KA1限制了食用面包后餐后血糖水平的升高。