CONACyT-Unidad de Investigacion Medica en Epidemiologia Clinica, Hospital de Pediatria, Centro Medico Siglo XXI, IMSS, 06720 Mexico City, Mexico.
Unidad de Investigacion Medica en Genética Humana, Hospital de Pediatria, Centro Medico Nacional Siglo XXI, IMSS, 06720 Mexico City, Mexico.
Int J Mol Sci. 2019 May 15;20(10):2394. doi: 10.3390/ijms20102394.
Acute lymphoblastic leukemia is the most common type of childhood cancer worldwide. Mexico City has one of the highest incidences and mortality rates of this cancer. It has previously been recognized that chromosomal translocations are important in cancer etiology. Specific fusion genes have been considered as important treatment targets in childhood acute lymphoblastic leukemia (ALL). The present research aimed at the identification and characterization of novel fusion genes with potential clinical implications in Mexican children with acute lymphoblastic leukemia. The RNA-sequencing approach was used. Four fusion genes not previously reported were identified: , , , . Although a fusion gene is not sufficient to cause leukemia, it could be involved in the pathogenesis of the disease. Notably, these new translocations were found in genes encoding for hematopoietic transcription factors which are known to play an important role in leukemogenesis and disease prognosis such as , , and . In addition, they may have an impact on the prognosis of Mexican pediatric patients with ALL, with the potential to be included in the current risk stratification schemes or used as therapeutic targets.
急性淋巴细胞白血病是全球最常见的儿童癌症类型。墨西哥城是这种癌症发病率和死亡率最高的城市之一。以前已经认识到染色体易位在癌症发病机制中很重要。特定的融合基因已被认为是儿童急性淋巴细胞白血病（ALL）的重要治疗靶点。本研究旨在鉴定和表征墨西哥儿童急性淋巴细胞白血病中具有潜在临床意义的新型融合基因。使用了 RNA 测序方法。鉴定出了四个以前未报道过的融合基因： 、 、 、 。虽然融合基因不足以导致白血病，但它可能参与疾病的发病机制。值得注意的是，这些新的易位发生在编码造血转录因子的基因中，这些基因已知在白血病发生和疾病预后中发挥重要作用，如 、 、 。此外，它们可能会影响墨西哥儿科 ALL 患者的预后，并有可能被纳入当前的风险分层方案或用作治疗靶点。
