Kalafut F, Hung P M, Novotná L, Grófová M
Neoplasma. 1978;25(5):569-75.
A modified form of the leukocyte adherence inhibition (LAI) test has been used to follow cell-mediated immunity (CMI) in rats of the Lewis inbred strain (LW), F1 hybrids inbred strains LW x AVN with transplanted syngeneic tumors B77, MC-1, and the random-bred Sprague Dawley strain with spontaneous REF tumor. Peripheral blood leukocytes of animals incubated witha specific tumor extract showed an adherence capacity by 30--40% lower than the same cell population cultured without this specific extract, or with a foreign nonspecific extract. The results are commented in connection with a possible application of this modified form of LAI test in studies of the immunological state of patients with a malignant disorder.
一种改良形式的白细胞黏附抑制（LAI）试验已被用于追踪Lewis近交系（LW）大鼠、近交系LW×AVN的F1杂种以及带有移植的同基因肿瘤B77、MC-1的大鼠，还有带有自发性REF肿瘤的随机繁殖的Sprague Dawley品系大鼠的细胞介导免疫（CMI）。用特定肿瘤提取物孵育的动物外周血白细胞显示出的黏附能力比在无该特定提取物或有外源非特异性提取物培养条件下的相同细胞群体低30%至40%。结合这种改良形式的LAI试验在恶性疾病患者免疫状态研究中的可能应用对结果进行了评论。
