Doğan Esra Sinem Kemer, Doğan Burak, Fentoğlu Özlem, Kırzıoğlu Fatma Yeşim
Department of Periodontology, Mustafa Kemal University Faculty of Dentistry, Hatay, Turkey.
Department of Periodontology, Süleyman Demirel University Faculty of Dentistry, Isparta, Turkey.
J Periodontal Implant Sci. 2019 Apr 24;49(2):105-113. doi: 10.5051/jpis.2019.49.2.105. eCollection 2019 Apr.
An unresolved inflammatory state contributes to the pathogenesis of periodontal disease and metabolic syndrome (MetS). Therefore, the purpose of this study was to evaluate the role of lipoxin A4 (LXA4), a proresolving lipid mediator, in the association between periodontal disease and MetS.
Sixty-seven patients with MetS and 65 patients without MetS were included in the study. Sociodemographic information was obtained via a questionnaire, and detailed medical diagnoses were made. Periodontal parameters (plaque index [PI], gingival index [GI], probing pocket depth [PD], and clinical attachment level [CAL]) and metabolic parameters were measured, and serum LXA4 levels were determined. The associations among MetS, periodontal parameters, and serum LX levels were evaluated by adjusted multivariate linear regression analyses.
Patients with MetS were older and had a higher body mass index than patients without MetS. Periodontal parameters (PI, GI, PD, and CAL) were higher in patients with MetS than in those without MetS. Serum LXA4 levels were higher in patients without MetS. Multivariate linear regression analysis indicated a positive association between MetS and periodontal parameters (PD and CAL). Negative associations were established between MetS and LXA4 levels, and between LXA4 and periodontal parameters (PI, PD, and CAL).
The presence of higher values of periodontal parameters in patients with MetS and the negative relationship of LXA4 with MetS and periodontal disease may support the protective role of proresolving lipid mediators in the association between periodontal disease and MetS.
未解决的炎症状态会促进牙周疾病和代谢综合征（MetS）的发病机制。因此，本研究的目的是评估促分解脂质介质脂氧素A4（LXA4）在牙周疾病与代谢综合征之间关联中的作用。
本研究纳入了67例代谢综合征患者和65例非代谢综合征患者。通过问卷获取社会人口统计学信息，并进行详细的医学诊断。测量牙周参数（菌斑指数[PI]、牙龈指数[GI]、探诊深度[PD]和临床附着水平[CAL]）和代谢参数，并测定血清LXA4水平。通过调整后的多变量线性回归分析评估代谢综合征、牙周参数和血清LXA4水平之间的关联。
代谢综合征患者比非代谢综合征患者年龄更大且体重指数更高。代谢综合征患者的牙周参数（PI、GI、PD和CAL）高于非代谢综合征患者。非代谢综合征患者的血清LXA4水平更高。多变量线性回归分析表明代谢综合征与牙周参数（PD和CAL）之间呈正相关。代谢综合征与LXA4水平之间以及LXA4与牙周参数（PI、PD和CAL）之间呈负相关。
代谢综合征患者牙周参数值较高，以及LXA4与代谢综合征和牙周疾病之间的负相关关系，可能支持促分解脂质介质在牙周疾病与代谢综合征关联中的保护作用。
