Chow Eric P F, Maddaford Kate, Trumpour Sabrina, Fairley Christopher K
Melbourne Sexual Health Centre, Alfred Health, 580 Swanston Street, Carlton, Vic. 3053, Australia; and Central Clinical School, Monash University, 99 Commercial Road, Melbourne, Vic. 3004, Australia; and Corresponding author. Email:
Melbourne Sexual Health Centre, Alfred Health, 580 Swanston Street, Carlton, Vic. 3053, Australia.
Sex Health. 2019 Sep;16(5):433-441. doi: 10.1071/SH18237.
The gonorrhoea rate among gay and bisexual men who have sex with men (MSM) has been increasing rapidly in many Western countries. Furthermore, gonorrhoea is becoming increasingly resistant to antibiotics and only limited options remain for treatment. Recent evidence suggests that the oropharynx may play an important role in gonorrhoea transmission. It is hypothesised that reducing the prevalence of oropharyngeal gonorrhoea will also reduce the population incidence of gonorrhoea. Mouthwash has been proposed as a novel non-antibiotic intervention to prevent oropharyngeal gonorrhoea; hence, reducing the probability of antibiotic resistance developing. However, its efficacy is yet to be confirmed by a randomised controlled trial - the findings of which will be available in 2019. If the trial shows mouthwash is effective in preventing gonorrhoea, this finding could potentially be translated into a public health campaign to increase the mouthwash use in the MSM population. This article summarises the current evidence of the effectiveness of mouthwash against gonorrhoea and discusses the potential literature gaps before implementing the mouthwash intervention at a population level.
在许多西方国家，男同性恋者和双性恋男性（与男性发生性行为的男性，简称MSM）中的淋病发病率一直在迅速上升。此外，淋病对抗生素的耐药性越来越强，可供治疗的选择非常有限。最近的证据表明，口咽部可能在淋病传播中起重要作用。据推测，降低口咽部淋病的患病率也将降低淋病的人群发病率。漱口水已被提议作为一种新型非抗生素干预措施来预防口咽部淋病；因此，降低产生抗生素耐药性的可能性。然而，其疗效尚未得到随机对照试验的证实——该试验结果将于2019年公布。如果试验表明漱口水在预防淋病方面有效，这一发现可能会转化为一场公共卫生运动，以增加MSM人群中漱口水的使用。本文总结了目前关于漱口水预防淋病有效性的证据，并讨论了在人群层面实施漱口水干预之前潜在的文献空白。
