人类T细胞亚群的自发及抗体依赖性细胞介导的细胞毒性作用
Spontaneous and antibody-dependent cell-mediated cytotoxicity by human T cell subpopulations.
作者信息
Gupta S, Fernandes G, Nair M, Good R A
出版信息
Proc Natl Acad Sci U S A. 1978 Oct;75(10):5137-41. doi: 10.1073/pnas.75.10.5137.
Human peripheral blood non-T cells, T cells and their subpopulations (Tmu, Tgamma, Tphi, Tgamma-depleted cells, and Tmu-depleted cells) were assayed for their capacity to mediated spontaneous lymphocyte-mediated cytotoxicity (SLMC) or natural killer activity against K562 tumor cell line and antibody-dependent cellular cytotoxicity (ADCC) against chicken erythrocytes coated with antibody. Non-T cells, unseparated T cells, Tgamma cells, and Tmu-depleted (Tgamma-enriched) cells were found to have both SLMC (NK activity) and ADCC. Tmu, Tphi, and Tgamma-depleted cells had minimal or no SLMC and ADCC activity. This study demonstrates that SLMC and ADCC activity in T cells is mediated by Tgamma cell subpopulations. These two cytotoxic reactions were either mediated by two distinct subsets of Tgamma cells or by a single effector cell using two different mechanisms.
对人类外周血非T细胞、T细胞及其亚群（Tmu、Tgamma、Tphi、Tgamma缺失细胞和Tmu缺失细胞）进行检测，以评估它们介导针对K562肿瘤细胞系的自发淋巴细胞介导细胞毒性（SLMC）或自然杀伤活性以及针对包被抗体的鸡红细胞的抗体依赖性细胞毒性（ADCC）的能力。发现非T细胞、未分离的T细胞、Tgamma细胞和Tmu缺失（Tgamma富集）细胞同时具有SLMC（NK活性）和ADCC。Tmu、Tphi和Tgamma缺失细胞具有最小或无SLMC和ADCC活性。本研究表明，T细胞中的SLMC和ADCC活性由Tgamma细胞亚群介导。这两种细胞毒性反应要么由Tgamma细胞的两个不同亚群介导，要么由单个效应细胞使用两种不同机制介导。
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