Cottrell G A, Robertson H A
Neuropharmacology. 1987 Jun;26(6):645-8. doi: 10.1016/0028-3908(87)90161-4.
Electrically kindled rats exhibit myoclonic jerks (1-25/min for 30-90 min) when injected with 200 mg/kg i.p. cysteamine. L-Baclofen, 10 mg/kg i.p. injected 45 min prior was not anticonvulsant but rather exacerbated the myoclonus. Furthermore, baclofen itself induced myoclonus in 29% of kindled rats at 10 mg/kg and in 100% of kindled rats at 15 mg/kg. These findings suggest that caution should be exercised before proposing the use of baclofen as an anticonvulsant or indeed using baclofen in patients who are predisposed to seizures.
给电点燃大鼠腹腔注射200mg/kg半胱胺后，会出现肌阵挛性抽搐（30 - 90分钟内每分钟1 - 25次）。提前45分钟腹腔注射10mg/kg的L - 巴氯芬并无抗惊厥作用，反而会加重肌阵挛。此外，巴氯芬本身在10mg/kg时会使29%的点燃大鼠诱发肌阵挛，在15mg/kg时会使100%的点燃大鼠诱发肌阵挛。这些发现表明，在提议将巴氯芬用作抗惊厥药物或在易发生癫痫的患者中实际使用巴氯芬之前，应谨慎行事。
