半胱胺对海马点燃大鼠癫痫发作的诱导与抑制作用
Induction and suppression of seizures by cysteamine in hippocampal kindled rats.
作者信息
Cottrell G A, Robertson H A
出版信息
Brain Res. 1986 Feb 19;365(2):393-6. doi: 10.1016/0006-8993(86)91657-4.
PMID:3948001
Abstract
Cysteamine has a biphasic effect in kindled rats. At a dose of 200 mg/kg (i.p.), hippocampal kindled rats all have myoclonic seizures during the first hour after injection, while naive rats seldom do. Four hours after cysteamine, the animals exhibited stage 5 seizures when stimulated. However, kindled seizures could not subsequently be elicited for up to 10 days in these animals.
摘要
半胱胺对点燃大鼠有双相作用。以200毫克/千克（腹腔注射）的剂量给药时，海马体点燃大鼠在注射后的第一小时内均出现肌阵挛性癫痫发作，而正常大鼠很少出现这种情况。注射半胱胺四小时后，动物在受到刺激时出现5期癫痫发作。然而，在这些动物中，随后长达10天都无法诱发点燃性癫痫发作。
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