Faculty of Natural Sciences, Thu Dau Mot University, Thu Dau Mot City 820000, Binh Duong province, Vietnam.
Department of Biochemistry, Faculty of Biology and Biotechnology, University of Science, Vietnam National University, Ho Chi Minh City 700000, Vietnam.
Biomolecules. 2019 May 18;9(5):195. doi: 10.3390/biom9050195.
The aminoethyl-chitooligosaccharide (AE-COS) was reported to inhibit human gastric cancer cell proliferation and human fibrosarcoma cell invasion. In this study, the role of AE-COS in down-regulation of proliferation of human lung A549 cancer cells was evaluated. It was found that AE-COS was able to reduce A549 cell proliferation to (32 ± 1.3)% at a concentration of 500 µg/ml. Moreover, AE-COS treatment caused suppression on COX-2 expression in a dose-dependent manner. Notably, the role of AE-COS in induction of cell apoptosis was observed via decreasing Bcl-2 expression and increasing caspase-3 and -9 activation. Accordingly, the antiproliferative effect of AE-COS was indicated due to suppression of cell proliferation and induction of cell apoptosis, suggesting AE-COS as a promising chemotherapy agent for treatment of lung cancer.
氨基乙基壳寡糖（AE-COS）被报道能抑制人胃癌细胞增殖和人纤维肉瘤细胞侵袭。在本研究中，评估了 AE-COS 下调人肺 A549 癌细胞增殖的作用。结果发现，AE-COS 能将 A549 细胞的增殖抑制在 500μg/ml 浓度时的（32±1.3）%。此外，AE-COS 处理呈浓度依赖性地抑制 COX-2 表达。值得注意的是，AE-COS 通过降低 Bcl-2 表达和增加 caspase-3 和 -9 的激活，诱导细胞凋亡。因此，AE-COS 具有抑制细胞增殖和诱导细胞凋亡的作用，提示 AE-COS 可能是一种有前途的肺癌化疗药物。
