Ibrahim Marwan A, Alhalafi Mona H, Emam El-Amir M, Ibrahim Hassan, Mosaad Rehab M
Department of Biology, College of Science, Majmaah University, Al-Majmaah 11952, Saudi Arabia.
Faculty of Women for Arts, Science and Education, Ain Shams University, Cairo 11566, Egypt.
Polymers (Basel). 2023 Jun 26;15(13):2820. doi: 10.3390/polym15132820.
Chitosan is produced by deacetylating the abundant natural chitin polymer. It has been employed in a variety of applications due to its unique solubility as well as its chemical and biological properties. In addition to being biodegradable and biocompatible, it also possesses a lot of reactive amino side groups that allow for chemical modification and the creation of a wide range of useful derivatives. The physical and chemical characteristics of chitosan, as well as how it is used in the food, environmental, and medical industries, have all been covered in a number of academic publications. Chitosan offers a wide range of possibilities in environmentally friendly textile processes because of its superior absorption and biological characteristics. Chitosan has the ability to give textile fibers and fabrics antibacterial, antiviral, anti-odor, and other biological functions. One of the most well-known and frequently used methods to create nanofibers is electrospinning. This technique is adaptable and effective for creating continuous nanofibers. In the field of biomaterials, new materials include nanofibers made of chitosan. Numerous medications, including antibiotics, chemotherapeutic agents, proteins, and analgesics for inflammatory pain, have been successfully loaded onto electro-spun nanofibers, according to recent investigations. Chitosan nanofibers have several exceptional qualities that make them ideal for use in important pharmaceutical applications, such as tissue engineering, drug delivery systems, wound dressing, and enzyme immobilization. The preparation of chitosan nanofibers, followed by a discussion of the biocompatibility and degradation of chitosan nanofibers, followed by a description of how to load the drug into the nanofibers, are the first issues highlighted by this review of chitosan nanofibers in drug delivery applications. The main uses of chitosan nanofibers in drug delivery systems will be discussed last.
壳聚糖是通过对丰富的天然几丁质聚合物进行脱乙酰化而产生的。由于其独特的溶解性以及化学和生物学特性，它已被应用于各种领域。除了具有生物可降解性和生物相容性外，它还拥有许多反应性氨基侧基，这使得它能够进行化学修饰并生成多种有用的衍生物。许多学术出版物都涵盖了壳聚糖的物理和化学特性，以及它在食品、环境和医疗行业中的应用方式。由于其优异的吸收性和生物学特性，壳聚糖在环保型纺织工艺中提供了广泛的可能性。壳聚糖能够赋予纺织纤维和织物抗菌、抗病毒、抗异味和其他生物学功能。电纺丝是制备纳米纤维最著名且最常用的方法之一。该技术适用于制备连续纳米纤维且效率高。在生物材料领域，新型材料包括由壳聚糖制成的纳米纤维。最近的研究表明，许多药物，包括抗生素、化疗药物、蛋白质和用于炎性疼痛的镇痛药，已成功负载到电纺纳米纤维上。壳聚糖纳米纤维具有几个特殊的品质，使其非常适合用于重要的药物应用，如组织工程、药物递送系统、伤口敷料和酶固定化。本文对壳聚糖纳米纤维在药物递送应用中的综述首先强调了壳聚糖纳米纤维的制备，接着讨论了壳聚糖纳米纤维的生物相容性和降解，然后描述了如何将药物负载到纳米纤维中。最后将讨论壳聚糖纳米纤维在药物递送系统中的主要用途。
