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HBB-deficient Macaca fascicularis monkey presents with human β-thalassemia.

作者信息

Huang Yan, Ding Chenhui, Liang Puping, Li Duanduan, Tang Yu, Meng Wei, Sun Hongwei, Lu Hongyu, Chen Yu, Chen Xueying, Huang Qunshan, Fang Jianpei, Zhou Canquan, Yang Shihua, Huang Junjiu

机构信息

College of Veterinary Medicine & Key Laboratory of Comprehensive Prevention and Control for Severe Clinical Animal Diseases of Guangdong Province, South China Agricultural University, Guangzhou, 510642, China.

Key Laboratory of Reproductive Medicine of Guangdong Province, The First Affiliated Hospital and School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275, China.

出版信息

Protein Cell. 2019 Jul;10(7):538-542. doi: 10.1007/s13238-019-0627-y.

DOI:10.1007/s13238-019-0627-y
PMID:31111443
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6588645/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a96e/6588672/7a77cf865ee7/13238_2019_627_Fig1a_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a96e/6588672/7a77cf865ee7/13238_2019_627_Fig1a_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a96e/6588672/7a77cf865ee7/13238_2019_627_Fig1a_HTML.jpg

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本文引用的文献

1
Genetic compensation triggered by mutant mRNA degradation.突变 mRNA 降解引发的遗传补偿。
Nature. 2019 Apr;568(7751):193-197. doi: 10.1038/s41586-019-1064-z. Epub 2019 Apr 3.
2
PTC-bearing mRNA elicits a genetic compensation response via Upf3a and COMPASS components.PTC 携带的 mRNA 通过 Upf3a 和 COMPASS 成分引发遗传补偿反应。
Nature. 2019 Apr;568(7751):259-263. doi: 10.1038/s41586-019-1057-y. Epub 2019 Apr 3.
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SIRT6 deficiency results in developmental retardation in cynomolgus monkeys.SIRT6 缺乏导致食蟹猴发育迟缓。
基因编辑猴子:回顾与展望。
Front Cell Dev Biol. 2022 Sep 8;10:913996. doi: 10.3389/fcell.2022.913996. eCollection 2022.
4
Multi-Omics Analysis in β-Thalassemia Using an Gene-Knockout Human Erythroid Progenitor Cell Model.β-地中海贫血的多组学分析采用基因敲除人红系祖细胞模型。
Int J Mol Sci. 2022 Mar 4;23(5):2807. doi: 10.3390/ijms23052807.
5
Gene editing and its applications in biomedicine.基因编辑及其在生物医学中的应用。
Sci China Life Sci. 2022 Apr;65(4):660-700. doi: 10.1007/s11427-021-2057-0. Epub 2022 Feb 18.
6
Embryo-Engineered Nonhuman Primate Models: Progress and Gap to Translational Medicine.胚胎工程非人灵长类动物模型:向转化医学发展的进展与差距
Research (Wash D C). 2021 Aug 21;2021:9898769. doi: 10.34133/2021/9898769. eCollection 2021.
Nature. 2018 Aug;560(7720):661-665. doi: 10.1038/s41586-018-0437-z. Epub 2018 Aug 22.
4
Gene Therapy in Patients with Transfusion-Dependent β-Thalassemia.输血依赖型β-地中海贫血症患者的基因治疗。
N Engl J Med. 2018 Apr 19;378(16):1479-1493. doi: 10.1056/NEJMoa1705342.
5
Cloning of Macaque Monkeys by Somatic Cell Nuclear Transfer.恒河猴体细胞克隆。
Cell. 2018 Feb 8;172(4):881-887.e7. doi: 10.1016/j.cell.2018.01.020. Epub 2018 Feb 1.
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J Blood Med. 2016 Nov 4;7:263-274. doi: 10.2147/JBM.S87955. eCollection 2016.
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