Student Research Committee, Nutrition Research Center, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Obes Rev. 2019 Jul;20(7):1057-1069. doi: 10.1111/obr.12853. Epub 2019 May 21.
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease. Recently, some novel compounds have been investigated for the prevention and treatment of NAFLD. Oleoylethanolamide (OEA), an endogenous PPAR-α agonist, has exhibited a plethora of pharmacological properties for the treatment of obesity and other obesity-associated metabolic complications. This systematic review was performed with a focus on the effects of OEA on the risk factors for NAFLD. PubMed, Scopus, Embase, ProQuest, and Google Scholar databases were searched up to December 2018 using relevant keywords. All articles written in English evaluating the effects of OEA on the risk factors for NAFLD were eligible for the review. The evidence reviewed in this article illustrates that OEA regulates multiple biological processes associated with NAFLD, including lipid metabolism, inflammation, oxidative stress, and energy homeostasis through different mechanisms. In summary, many beneficial effects of OEA have led to the understanding that OEA may be an effective therapeutic strategy for the management of NAFLD. Although a wide range of studies have demonstrated the most useful effects of OEA on NAFLD and the associated risk factors, further clinical trials, from both in vivo studies and in vitro experiments, are warranted to verify these outcomes.
非酒精性脂肪性肝病（NAFLD）是最常见的慢性肝病。最近，一些新型化合物已被用于预防和治疗 NAFLD。油酰乙醇酰胺（OEA）是一种内源性 PPAR-α 激动剂，具有治疗肥胖症和其他肥胖相关代谢并发症的多种药理学特性。本系统评价重点关注 OEA 对 NAFLD 危险因素的影响。使用相关关键词在 PubMed、Scopus、Embase、ProQuest 和 Google Scholar 数据库中搜索至 2018 年 12 月。所有评估 OEA 对 NAFLD 危险因素影响的英文文章均符合本综述的纳入标准。本文综述的证据表明，OEA 通过不同机制调节与 NAFLD 相关的多种生物学过程，包括脂质代谢、炎症、氧化应激和能量稳态。总之，OEA 的许多有益作用使人们认识到，OEA 可能是治疗 NAFLD 的有效治疗策略。尽管大量研究表明 OEA 对 NAFLD 和相关危险因素最有效，但仍需要进一步的临床研究，包括体内研究和体外实验，以验证这些结果。
