Bahari Hossein, Jazinaki Mostafa Shahraki, Aghakhani Ladan, Hatami Alireza, Rahnama Iman, Malekahmadi Mahsa
Transplant Research Center, Clinical Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.
Front Nutr. 2025 May 21;12:1553288. doi: 10.3389/fnut.2025.1553288. eCollection 2025.
Oleoylethanolamide (OEA) is a naturally occurring lipid that has been studied for its potential role in weight management and metabolic health. Through comprehensive meta-analysis, we aim to clarify the potential benefits of OEA in improving inflammation, oxidative stress, and metabolic parameters.
To identify relevant randomized controlled trials (RCTs), a comprehensive search was conducted using Google Scholar and four databases: PubMed, Embase, Scopus, and Web of Science, up to November 2024. Eligible trials were detected by screening, and related data were extracted, respectively. Pooled effect sizes were calculated using meta-analyses and expressed as standard mean difference (SMD) with a 95% confidence interval (CI).
Ten trials (with 11 treatment arms) were eligible for inclusion in this review. Meta-analysis revealed that OEA supplementation led to a significant improvement in C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), total antioxidant capacity (TAC), malondialdehyde (MDA), body weight, body mass index (BMI), waist circumference (WC), fat mass (FM), body fat percentage (BFP), triglycerides (TG), fasting blood glucose (FBG), insulin, and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) levels. However, no significant changes were observed in interleukin 6 (IL-6), fat-free mass (FFM), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and hemoglobin A1C (HbA1c) following OEA intake.
Supplementation with OEA may help improve glycemic control, weight loss, waist circumference, fat mass, fat percentage, inflammation, and oxidative stress. However, further research is needed to establish definitive conclusions regarding its efficacy and long-term benefits.
油酰乙醇胺（OEA）是一种天然存在的脂质，其在体重管理和代谢健康方面的潜在作用已得到研究。通过全面的荟萃分析，我们旨在阐明OEA在改善炎症、氧化应激和代谢参数方面的潜在益处。
为了识别相关的随机对照试验（RCT），截至2024年11月，使用谷歌学术以及四个数据库（PubMed、Embase、Scopus和Web of Science）进行了全面检索。通过筛选检测出符合条件的试验，并分别提取相关数据。使用荟萃分析计算合并效应量，并以95%置信区间（CI）的标准平均差（SMD）表示。
十项试验（含11个治疗组）符合纳入本综述的条件。荟萃分析显示，补充OEA可显著改善C反应蛋白（CRP）、肿瘤坏死因子-α（TNF-α）、总抗氧化能力（TAC）、丙二醛（MDA）、体重、体重指数（BMI）、腰围（WC）、脂肪量（FM）、体脂百分比（BFP）、甘油三酯（TG）、空腹血糖（FBG）、胰岛素以及胰岛素抵抗稳态模型评估（HOMA-IR）水平。然而，摄入OEA后，白细胞介素6（IL-6）、去脂体重（FFM）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）和糖化血红蛋白（HbA1c）未观察到显著变化。
补充OEA可能有助于改善血糖控制、体重减轻、腰围、脂肪量、脂肪百分比、炎症和氧化应激。然而，需要进一步研究以确定其疗效和长期益处的确切结论。
