Su Lin-Lin, Chang Xiao-Jing, Zhou Huan-Di, Hou Liu-Bing, Xue Xiao-Ying
Department of Radiotherapy, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China.
World J Clin Cases. 2019 Apr 26;7(8):908-916. doi: 10.12998/wjcc.v7.i8.908.
Exosomes are nanovesicles secreted from various types of cells and can be isolated from various bodily fluids, such as blood and urine. The number and molecular contents, including proteins and RNA of exosomes, have been shown to reflect their parental cell origins, characteristics and biological behaviors. An increasing number of studies have demonstrated that exosomes play a role in the course of tumorigenesis, diagnosis, treatment and prognosis, although its precise functions in tumors are still unclear. Moreover, owing to a lack of a standard approach, exosomes and its contents have not yet been put into clinical practice successfully. This review aims to summarize the current knowledge on exosomes and its contents in esophageal cancer as well as the current limitations/challenges in its clinical application, which may provide a basis for an all-around understanding of the implementation of exosomes and exosomal contents in the surveillance and therapy of esophageal cancer.
外泌体是由各种类型的细胞分泌的纳米囊泡，可从各种体液中分离出来，如血液和尿液。外泌体的数量和分子成分，包括蛋白质和RNA，已被证明能反映其母细胞来源、特征和生物学行为。越来越多的研究表明，外泌体在肿瘤发生、诊断、治疗和预后过程中发挥作用，尽管其在肿瘤中的精确功能仍不清楚。此外，由于缺乏标准方法，外泌体及其内容物尚未成功应用于临床实践。本综述旨在总结目前关于食管癌中外泌体及其内容物的知识，以及其临床应用中的当前局限性/挑战，这可能为全面了解外泌体及其内容物在食管癌监测和治疗中的应用提供依据。
