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Resistance to meningococcemia apparently conferred by anti-H.8 monoclonal antibody is due to contaminating endotoxin and not to specific immunoprotection.抗H.8单克隆抗体对脑膜炎球菌血症的明显抗性是由内毒素污染所致，而非特异性免疫保护。
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本文引用的文献

1
NEISSERIA GONORRHOEAE. I. VIRULENCE GENETICALLY LINKED TO CLONAL VARIATION.淋病奈瑟菌。一、与克隆变异基因连锁的毒力。
J Bacteriol. 1963 Jun;85(6):1274-9. doi: 10.1128/jb.85.6.1274-1279.1963.
2
Monoclonal antibody that recognizes an outer membrane antigen common to the pathogenic Neisseria species but not to most nonpathogenic Neisseria species.一种单克隆抗体，可识别致病性奈瑟菌属共有的外膜抗原，但大多数非致病性奈瑟菌属不具有该抗原。
Infect Immun. 1984 Mar;43(3):994-9. doi: 10.1128/iai.43.3.994-999.1984.
3
Monoclonal antibodies against Neisseria gonorrhoeae: production of antibodies directed against a strain-specific cell surface antigen.抗淋病奈瑟菌单克隆抗体：针对菌株特异性细胞表面抗原的抗体产生
Infect Immun. 1981 May;32(2):641-8. doi: 10.1128/iai.32.2.641-648.1981.
4
The meningococcus and mechanisms of pathogenicity.脑膜炎球菌与致病机制
Microbiol Rev. 1982 Jun;46(2):162-90. doi: 10.1128/mr.46.2.162-190.1982.
5
Effects of endotoxins on susceptibility to infections.内毒素对感染易感性的影响。
J Infect Dis. 1970 Sep;122(3):205-15. doi: 10.1093/infdis/122.3.205.
6
Neisserial antigen H.8 is immunogenic in patients with disseminated gonococcal and meningococcal infections.奈瑟菌抗原H.8在播散性淋球菌感染和脑膜炎球菌感染患者中具有免疫原性。
J Infect Dis. 1985 Apr;151(4):650-7. doi: 10.1093/infdis/151.4.650.
7
Isolation and preliminary biochemical characterization of the gonococcal H.8 antigen.淋球菌H.8抗原的分离及初步生化特性分析
J Exp Med. 1986 Dec 1;164(6):2038-48. doi: 10.1084/jem.164.6.2038.
8
Analyses of gonococcal H8 antigen. Surface location, inter- and intrastrain electrophoretic heterogeneity, and unusual two-dimensional electrophoretic characteristics.淋球菌H8抗原分析。表面定位、菌株间和菌株内电泳异质性以及异常的二维电泳特征。
J Exp Med. 1985 Dec 1;162(6):2017-34. doi: 10.1084/jem.162.6.2017.
9
Inflammatory effects of endotoxin-like contaminants in commonly used protein preparations.
Science. 1977 Apr 1;196(4285):83-5. doi: 10.1126/science.557238.
10
The effects of bacterial endotoxins on host mediation systems. A review.细菌内毒素对宿主介导系统的影响。综述。
Am J Pathol. 1978 Nov;93(2):526-618.

抗H.8单克隆抗体对脑膜炎球菌血症的明显抗性是由内毒素污染所致，而非特异性免疫保护。

Resistance to meningococcemia apparently conferred by anti-H.8 monoclonal antibody is due to contaminating endotoxin and not to specific immunoprotection.

作者信息

Woods J P, Black J R, Barritt D S, Connell T D, Cannon J G

出版信息

Infect Immun. 1987 Aug;55(8):1927-8. doi: 10.1128/iai.55.8.1927-1928.1987.

DOI:10.1128/iai.55.8.1927-1928.1987
PMID:3112017
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC260627/
Abstract

We evaluated the ability of a monoclonal antibody directed against the common H.8 antigen of pathogenic Neisseria sp. to confer passive protection against meningococcal disease in mice. The apparent protection conferred by antibody purified from tissue culture supernatant was actually the result of endotoxin contamination of buffers and tissue culture media. Endotoxin-free anti-H.8 antibody was not protective. The possibility of endotoxin contamination should be considered when evaluating immunity conferred by passively administered antibody in animal models.

摘要

我们评估了一种针对致病性奈瑟菌属常见H.8抗原的单克隆抗体在小鼠中提供被动保护以抵御脑膜炎球菌病的能力。从组织培养上清液中纯化的抗体所赋予的明显保护实际上是缓冲液和组织培养基中内毒素污染的结果。无内毒素的抗H.8抗体没有保护作用。在评估动物模型中被动给予抗体所赋予的免疫力时，应考虑内毒素污染的可能性。