Just H M, Termöhlen M, Pinkawa M, Daschner F D
Infection. 1987;15 Suppl 2:S42-6. doi: 10.1007/BF01644191.
The in vitro influence of a pseudomonas immunoglobulin in active and inactivated serum on the bactericidal activity and phagocytosis of human polymorphonuclear leukocytes was evaluated against Pseudomonas aeruginosa. No lysis of the bacteria could be found in either serum, however, the bactericidal activity of the leukocytes was significantly enhanced in active serum (p less than or equal to 0.05), whereas no effect was measurable in inactivated serum. Phagocytosis could be increased in concentrations of 10% immunoglobulin, (equivalent to 5 mg IgG/ml); however, a concentration of 15% showed a lower phagocytosis index which was comparable to that in the 5% preparation. This immunoglobulin proved to be able to support the bacterial phagocytosis and killing of P. aeruginosa by human polymorphonuclear leukocytes in vitro.
评估了一种假单胞菌免疫球蛋白在活性血清和灭活血清中对人多形核白细胞针对铜绿假单胞菌的杀菌活性和吞噬作用的体外影响。在两种血清中均未发现细菌裂解，然而，白细胞的杀菌活性在活性血清中显著增强（p小于或等于0.05），而在灭活血清中未检测到作用。在免疫球蛋白浓度为10%（相当于5mg IgG/ml）时吞噬作用可增强；然而，15%的浓度显示出较低的吞噬指数，与5%制剂中的吞噬指数相当。这种免疫球蛋白在体外被证明能够支持人多形核白细胞对铜绿假单胞菌的细菌吞噬和杀灭作用。
