Hamajima N, Lee J A
Jpn J Cancer Res. 1987 Jun;78(6):547-58.
The mortality data on stomach cancer in Japan during 1955 to 1980 were analyzed by the use of an age-period-cohort model. Although the model could not give a unique solution of age, period, and cohort parameters, several sets of estimates of the parameters clarified particular features of each effect. Within a plausible range, the features were as follows. The period parameter underwent linear change from 1965 to 1980 for males and from 1970 to 1980 for females. The cohort parameters decreased birth cohort by birth cohort, at least among those who were born after 1891. The curve of the age parameter in females showed a shoulder around age 40 and a subsequent upward slope to age 80, while that in males was unimodal. The curve in females was compatible with the idea that there might be two different main entities in stomach cancer. The model also gave estimates of future trends in stomach cancer mortality under the assumption that there would be no additional change in period effect other than that expected from the recent quinquennia. The number of deaths from stomach cancer in males would be rather stable until 2000, and that in females would decline slightly. The age-adjusted and crude mortality rates would continue to decrease at least until 2000.
利用年龄-时期-队列模型对1955年至1980年日本胃癌死亡率数据进行了分析。尽管该模型无法给出年龄、时期和队列参数的唯一解,但几组参数估计值阐明了每种效应的特定特征。在合理范围内,这些特征如下。男性的时期参数在1965年至1980年呈线性变化,女性的时期参数在1970年至1980年呈线性变化。队列参数逐出生队列下降,至少在1891年以后出生的人群中如此。女性年龄参数曲线在40岁左右出现一个峰值,随后至80岁呈上升趋势,而男性的年龄参数曲线是单峰的。女性的曲线与胃癌可能存在两种不同主要类型的观点相符。该模型还在假设除最近五年预期的时期效应变化外不会有其他额外变化的情况下,对胃癌死亡率的未来趋势进行了估计。男性胃癌死亡人数在2000年前将相当稳定,女性胃癌死亡人数将略有下降。年龄调整死亡率和粗死亡率至少在2000年前将继续下降。