Zhang Jing-Xiang, Chan Wai-Lun, Xie Chen, Zhou Yan, Chau Ho-Fai, Maity Partha, Harrison George T, Amassian Aram, Mohammed Omar F, Tanner Peter A, Wong Wai-Kwok, Wong Ka-Leung
1Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong S.A.R., China.
2Hanshan Normal University, Chaozhou, Guangdong Province China.
Light Sci Appl. 2019 May 22;8:46. doi: 10.1038/s41377-019-0155-9. eCollection 2019.
Although lanthanide double-decker complexes with hetero-macrocyclic ligands as functional luminescent and magnetic materials have promising properties, their inferior water solubility has negated their biomedical applications. Herein, four water-soluble homoleptic lanthanide ( , , and ) sandwiches with diethylene-glycol-disubstituted porphyrins () are reported, with their structures proven by both quantum chemical calculations and scanning tunneling microscopy. Our findings demonstrate that the near-infrared emission intensity and singlet oxygen (O) quantum yields of and in aqueous media are higher than those of the reported capped lanthanide monoporphyrinato analogues, and ; the brightness and luminescence lifetime in water of are greater than those of . This work provides a new dimension for the future design and development of molecular theranostics-based water-soluble double-decker lanthanide bisporphyrinates.
尽管具有杂环大环配体的镧系元素双层配合物作为功能性发光和磁性材料具有良好的性能，但其较差的水溶性却限制了它们在生物医学领域的应用。在此，我们报道了四种具有二甘醇二取代卟啉（）的水溶性均配镧系元素（、、和）夹心配合物，其结构通过量子化学计算和扫描隧道显微镜得到证实。我们的研究结果表明，在水性介质中，和的近红外发射强度和单线态氧（O）量子产率高于已报道的封端镧系单卟啉类似物和；在水中的亮度和发光寿命大于。这项工作为基于分子诊疗的水溶性双层镧系双卟啉酸盐的未来设计和开发提供了新的思路。
