Institute of Poultry Science, Shandong Academy of Agricultural Sciences, Ji'nan, China.
Transbound Emerg Dis. 2019 Sep;66(5):2171-2174. doi: 10.1111/tbed.13258. Epub 2019 Jun 11.
Avian paramyxovirus type 4 (APMV-4) has been frequently reported from wildfowl and waterfowl in recent year. However, few studies have reported on the molecular characteristics and regional transmission of APMV-4, knowledge of which is important for understanding the genetic diversity and epidemiology of avian paramyxovirus. Herein, we report the isolation of one APMV-4 strain, designated as QY17, from the duck in eastern China. The determined complete genome of the isolate with six gene segments 3'-N-P-M-F-HN-L-5' was 15,054 nt in length. Genetic analysis of the whole-fusion gene of this isolate showed that QY17 was derived from a Eurasian lineage. Further phylogenetic analysis showed that the duck-origin strain QY17 had a highly genetic relationship with representative APMV-4 strains from wildfowl in neighbouring regions. These genetic results suggested that APMV-4 viral exchange may occur in wildfowl and poultry via wild bird migration.
禽副黏病毒 4 型（APMV-4）近年来在野生水禽和家禽中频繁报道。然而，关于 APMV-4 的分子特征和区域传播的研究较少，了解这些特征对于理解禽副黏病毒的遗传多样性和流行病学具有重要意义。本研究报告了从中国东部的鸭子中分离到一株 APMV-4 病毒株，命名为 QY17。该分离株的全基因组由 6 个基因片段 3'-N-P-M-F-HN-L-5'组成，全长 15054nt。该分离株全融合基因的遗传分析表明，QY17 来源于欧亚谱系。进一步的系统进化分析表明，鸭源分离株 QY17 与来自邻近地区野生鸟类的代表性 APMV-4 株具有高度的遗传关系。这些遗传结果表明，APMV-4 病毒可能通过野生鸟类迁徙在野生鸟类和家禽之间发生交换。
