Mohsenifar Z, Amin D, Jasper A C, Shah P K, Koerner S K
Chest. 1987 Sep;92(3):447-50. doi: 10.1378/chest.92.3.447.
We previously have shown that in patients with adult respiratory distress syndrome (ARDS) oxygen consumption (VO2) is linearly related to oxygen delivery (DO2) below a threshold DO2 of 21 ml/min/kg. To evaluate this relationship in chronic congestive heart failure (CHF), we studied eight patients with chronic CHF at baseline and during treatment with nitroglycerin. The resting DO2 and VO2 were 10.7 +/- 2.3 ml/min/kg and 3.8 +/- 0.87 ml/min/kg, respectively. In our eight patients, we found a significant relationship between changes in VO2 and in DO2 (delta VO2 = 0.16 + 0.34 X delta DO2, r = 0.84, n = 29). There was no significant relationship between DO2 and mixed venous oxygen tension (PvO2, r = 0.16), nor was there a significant relationship between cardiac output (Qt) and PvO2 (r = 0.21). We conclude that in patients with chronic CHF, changes in VO2 appear to be dependent on changes in DO2. This may represent an adaptive tissue response to chronically reduced systemic oxygen transport.
我们之前已经表明，在成人呼吸窘迫综合征（ARDS）患者中，低于21毫升/分钟/千克的阈值氧输送（DO2）时，氧消耗（VO2）与氧输送呈线性相关。为了评估慢性充血性心力衰竭（CHF）中的这种关系，我们在基线时以及使用硝酸甘油治疗期间研究了8例慢性CHF患者。静息DO2和VO2分别为10.7±2.3毫升/分钟/千克和3.8±0.87毫升/分钟/千克。在我们的8例患者中，我们发现VO2变化与DO2变化之间存在显著关系（ΔVO2 = 0.16 + 0.34×ΔDO2，r = 0.84，n = 29）。DO2与混合静脉血氧分压（PvO2，r = 0.16）之间无显著关系，心输出量（Qt）与PvO2之间也无显著关系（r = 0.21）。我们得出结论，在慢性CHF患者中，VO2变化似乎取决于DO2变化。这可能代表了组织对长期系统性氧输送减少的适应性反应。
