Anzawa Daisuke, Mawatari Takashi, Tanaka Yoshiyuki, Yamamoto Mio, Genda Tomomi, Takahashi Shota, Nishijima Tomohiko, Kamasaka Hiroshi, Suzuki Satoru, Kuriki Takashi
Institute of Health Sciences Ezaki Glico Co., Ltd. Osaka Japan.
Shinagawa Season Terrace Health Care Clinic Tokyo Japan.
Food Sci Nutr. 2019 Apr 21;7(5):1828-1837. doi: 10.1002/fsn3.1033. eCollection 2019 May.
A number of studies have shown the bifidogenic effects of either probiotic bifidobacteria or inulin, and this bifidogenic shift in the composition of the colonic microbiota is likely the basis for their positive impact on human health. This study aimed to evaluate the effects of synbiotics containing the probiotic bacterium subsp. () GCL2505 and inulin on the levels of intestinal bifidobacteria compared with GCL2505 alone. A randomized, double-blind, placebo-controlled, crossover trial was carried out involving 60 healthy subjects with a tendency for constipation using fermented milk containing GCL2505 and inulin (synbiotic), only GCL2505 (probiotic), and placebo. Fecal samples were collected at the end of each 2-week intervention period, and the bifidobacterial count was analyzed by quantitative real-time PCR. The numbers of total bifidobacteria and in feces were significantly increased during the probiotic and synbiotic intake periods compared with the placebo intake period. Furthermore, the numbers of total bifidobacteria and endogenous bifidobacteria were significantly higher in the synbiotic intake period compared with the probiotic intake period, while there was no difference in the number of . These results suggested that the synbiotics containing GCL2505 and inulin had a greater effect on the number of bifidobacteria than a drink containing probiotics alone and could be useful for the improvement of the intestinal environment.
多项研究表明，益生菌双歧杆菌或菊粉具有双歧杆菌生成作用，而结肠微生物群组成的这种双歧杆菌生成转变可能是它们对人类健康产生积极影响的基础。本研究旨在评估含有益生菌 亚种（）GCL2505和菊粉的合生元与单独使用GCL2505相比，对肠道双歧杆菌水平的影响。对60名有便秘倾向的健康受试者进行了一项随机、双盲、安慰剂对照的交叉试验，使用含有GCL2505和菊粉的发酵乳（合生元）、仅含GCL2505的发酵乳（益生菌）和安慰剂。在每2周干预期结束时收集粪便样本，并通过定量实时PCR分析双歧杆菌计数。与安慰剂摄入期相比，在益生菌和合生元摄入期，粪便中总双歧杆菌和 的数量显著增加。此外，与益生菌摄入期相比，合生元摄入期总双歧杆菌和内源性双歧杆菌的数量显著更高，而 的数量没有差异。这些结果表明，含有GCL2505和菊粉的合生元对双歧杆菌数量的影响比仅含益生菌的饮品更大，可能有助于改善肠道环境。
