a Risk Assessment on Food Safety and Pesticides Group (ERIA) , National Institute of Health (INS) , Bogota , Colombia.
b System of Chemical Risk Analyses on Food and Beverages Group, Food and Beverages Direction , National Institute of Food and Drug Surveillance (Invima) , Bogota , Colombia.
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2019 Jul;36(7):1109-1117. doi: 10.1080/19440049.2019.1615643. Epub 2019 May 29.
The aim of this research was to evaluate dietary exposure to aflatoxin B1 (AFB) in corn arepas in Colombia. In addition, in this study an assessment considering compliance to the maximum level of AFB (4 µg kg) for this food was conducted. AFB concentration data in corn arepas were obtained from 168 samples. The samples were collected from factories in 16 departments in Colombia. AFB was quantified by High-Performance Liquid Chromatography with a fluorescence detector. Consumption data and body weight (b.w.) were measured from the 2005 Colombian National Survey of Nutritional Status. Probabilistic estimates were made by Monte Carlo simulation of dietary exposure and margin of exposure (MOE) segmented by age group. The results showed that 27% of corn arepa samples were contaminated with AFB, with an average concentration of 15.1 µg kg and a maximum value of 111.1 µg kg. The stochastic dietary exposure assessment showed that the age group most exposed was children between 4 and 8 years old (10.014 ng (kg b.w. day)). In addition, the MOE values for all age groups were lower than 10,000, indicating a potential risk for consumers. However, in the scenario where AFB concentration level complies with the maximum limit of 4 µg kg AFB, the level of concern could be reduced for the adult population between 14 and 64 years old because the MOE value is above 10,000.
本研究旨在评估哥伦比亚玉米玉米饼中黄曲霉毒素 B1（AFB）的膳食暴露情况。此外，本研究还对该食品中 AFB 最大限量（4μgkg）的合规性进行了评估。从 168 个样本中获得了玉米玉米饼中 AFB 的浓度数据。这些样本是从哥伦比亚 16 个地区的工厂收集的。通过高效液相色谱法和荧光检测器定量测定 AFB。消耗数据和体重（b.w.）是从 2005 年哥伦比亚国家营养状况调查中测量的。通过 Monte Carlo 模拟对膳食暴露和暴露边际（MOE）进行概率估计，并按年龄组进行分段。结果表明，27%的玉米玉米饼样品受到 AFB 污染，平均浓度为 15.1μgkg，最高值为 111.1μgkg。随机膳食暴露评估显示，暴露程度最高的年龄组是 4 至 8 岁的儿童（10.014ng（kg b.w.天））。此外，所有年龄组的 MOE 值均低于 10,000，表明消费者存在潜在风险。然而，在 AFB 浓度水平符合 4μgkg AFB 的最大限量的情况下，14 至 64 岁的成年人群体的关注水平可能会降低，因为 MOE 值高于 10,000。
