Carter D M, Lin A N, Varghese M C, Caldwell D, Pratt L A, Eisinger M
J Am Acad Dermatol. 1987 Aug;17(2 Pt 1):246-50. doi: 10.1016/s0190-9622(87)70199-6.
We have successfully treated chronic facial erosions in three boys with junctional epidermolysis bullosa. In each patient, keratinocytes were harvested from the roof of suction blisters created on clinically uninvolved skin. They were grown in tissue culture on collagen sponges and grafted onto facial erosions that were previously treated with 2% mupirocin ointment. This experimental antibiotic ointment has proved efficacy in eradicating cutaneous pathogens such as Staphylococcus aureus from chronic wounds. In two patients, complete reepithelialization was achieved over 7 and 10 months, respectively, and partial reepithelialization occurred in another patient in whom treatment is ongoing. Epidermal autografts are a promising means for improving function and appearance in eroded skin caused by junctional epidermolysis bullosa.
我们成功治疗了三名患有交界性大疱性表皮松解症的男孩的慢性面部糜烂。在每位患者身上，从临床未受累皮肤产生的抽吸水疱顶部采集角质形成细胞。将它们在胶原海绵上进行组织培养，并移植到先前用2%莫匹罗星软膏治疗过的面部糜烂处。这种实验性抗生素软膏已被证明在根除慢性伤口中的皮肤病原体如金黄色葡萄球菌方面有效。在两名患者中，分别在7个月和10个月实现了完全上皮再生，另一名正在接受治疗的患者发生了部分上皮再生。自体表皮移植是改善交界性大疱性表皮松解症所致糜烂皮肤功能和外观的一种有前景的方法。
