Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Peoples Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Department of Preventive Medicine, Shantou University Medical College, Shantou, China.
BMJ Open. 2019 May 29;9(5):e028007. doi: 10.1136/bmjopen-2018-028007.
There are country and regional variations in the prevalence of hyperuricaemia (HUA). The prevalence of HUA and non-valvular atrial fibrillation (NVAF) in southern China is unknown.
A cross-sectional study.
A total of 11 488 permanent residents aged 35 or older from urban and rural areas of Guangzhou, China were enrolled. A questionnaire was used to compile each participant's demographic information and relevant epidemiological factors for HUA and NVAF. All participants were assessed using a panel of blood tests and single-lead 24-hour ECG.
HUA was defined as serum uric acid level >420 μmol/L in men and >360 μmol/L in women. NVAF was diagnosed as per guidelines.
The prevalence of HUA was 39.6% (44.8% in men and 36.7% in women), and 144 residents (1.25%) had NVAF. Prevalence of HUA increased with age in women but remained stably high in men. After adjusting for potential confounders, age, living in urban areas, alcohol consumption, central obesity, elevated fasting plasma glucose level, elevated blood pressure, lower high-density lipoprotein cholesterol level and elevated triglycerides level were associated with increased risk of HUA. Residents with HUA were at higher risk for NVAF. Serum uric acid level had a modest predictive value for NVAF in women but not men.
HUA was highly prevalent among citizens of southern China and was a predictor of NVAF among women.
高尿酸血症（HUA）的流行情况存在国家和地区差异。中国南方地区 HUA 和非瓣膜性心房颤动（NVAF）的流行情况尚不清楚。
横断面研究。
共纳入来自中国广州城乡地区的 11488 名年龄在 35 岁及以上的常住居民。使用问卷收集每位参与者的人口统计学信息和与 HUA 和 NVAF 相关的流行病学因素。所有参与者均接受了一系列血液检查和单导联 24 小时心电图评估。
HUA 定义为男性血清尿酸水平>420 μmol/L，女性>360 μmol/L。NVAF 按照指南进行诊断。
HUA 的患病率为 39.6%（男性为 44.8%，女性为 36.7%），有 144 名居民（1.25%）患有 NVAF。女性的 HUA 患病率随年龄增长而增加，但男性患病率保持稳定较高。在调整了潜在混杂因素后，年龄、居住在城市地区、饮酒、中心性肥胖、空腹血糖升高、血压升高、高密度脂蛋白胆固醇水平降低和甘油三酯水平升高与 HUA 风险增加相关。患有 HUA 的居民患 NVAF 的风险更高。血清尿酸水平对女性 NVAF 具有适度的预测价值，但对男性没有预测价值。
中国南方地区居民 HUA 患病率较高，且 HUA 是女性 NVAF 的预测因素。
