饮酒与成年人高尿酸血症风险之间的关联：来自中国重庆的一项大型横断面研究。

Association between alcohol consumption and risk of hyperuricaemia among adults: a large cross-sectional study in Chongqing, China.

机构信息

School of Public Health, Chongqing Medical University, Chongqing, China.

First clinical medical college, Chongqing Medical University, Chongqing, China.

出版信息

BMJ Open. 2023 Dec 13;13(12):e074697. doi: 10.1136/bmjopen-2023-074697.

DOI:10.1136/bmjopen-2023-074697

PMID:38097239

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10729094/

Abstract

OBJECTIVE

To investigate the relationship between alcohol consumption and hyperuricaemia (HUA), we conducted a study based on a large population.

SETTING

Cross-sectional study.

PARTICIPANTS

A total of 20 833 participants aged 30-79 years were enrolled in the China Multi-Ethnic Cohort, Chongqing region.

OUTCOMES

The serum level of uric acid, fasting blood glucose and blood lipids were tested. Basic demographic statistics such as age, gender, marital status, education level, family annual income and the detail information of alcohol consumption were collected using a standardised questionnaire.

RESULTS

After controlling for potential confounders, compared with participants who never consumed alcohol, participants who drank 3-5 days per week had the highest risk of HUA (OR: 1.51, 95% CI: 1.25 to 1.82) and those who drank alcohol harmfully had the highest risk of HUA (OR: 1.81, 95% CI: 1.41 to 2.32). In addition, we found that those who drank moderately had no significant association with risk of HUA. However, among men, compared with participants who never consumed alcohol, those who drank moderately was also a risk factor of HUA (OR: 1.23, 95% CI: 1.03 to 1.46) and those who drank alcohol harmfully had the highest risk of HUA (OR: 2.13, 95% CI: 1.64 to 2.78). Compared with participants who drank alcohol moderately, the OR (95% CI) for those who drank alcohol harmfully had the highest risk of HUA was 1.88 (1.42 to 2.48), and the corresponding OR (95% CI) for each level increment in the degree of alcohol consumption was 1.22 (1.12 to 1.33). Among men, compared with participants who drank alcohol moderately, those who drank alcohol harmfully had the highest risk of HUA (OR: 1.93, 95% CI: 1.45 to 2.57), as well as the corresponding OR (95% CI) for each level increment in the degree of alcohol consumption was 1.24 (1.13 to 1.35).

CONCLUSION

This study suggested that the frequency and degree of alcohol consumption may be the risk factors for HUA, especially in males.

摘要

目的

为了探讨饮酒与高尿酸血症（HUA）之间的关系，我们进行了一项基于大样本的研究。

设置

横断面研究。

参与者

共纳入中国多民族队列研究重庆地区 20833 名 30-79 岁的参与者。

结局

检测血清尿酸、空腹血糖和血脂水平。采用标准化问卷收集年龄、性别、婚姻状况、教育水平、家庭年收入等基本人口统计学资料和饮酒详细信息。

结果

在控制潜在混杂因素后，与从不饮酒者相比，每周饮酒 3-5 天者发生 HUA 的风险最高（OR：1.51，95%CI：1.25 至 1.82），有害饮酒者发生 HUA 的风险最高（OR：1.81，95%CI：1.41 至 2.32）。此外，我们发现适量饮酒者与 HUA 风险无显著关联。然而，在男性中，与从不饮酒者相比，适量饮酒者也是 HUA 的危险因素（OR：1.23，95%CI：1.03 至 1.46），有害饮酒者发生 HUA 的风险最高（OR：2.13，95%CI：1.64 至 2.78）。与适量饮酒者相比，有害饮酒者发生 HUA 的风险最高（OR：1.88，95%CI：1.42 至 2.48），且饮酒程度每增加一个等级，OR（95%CI）为 1.22（1.12 至 1.33）。在男性中，与适量饮酒者相比，有害饮酒者发生 HUA 的风险最高（OR：1.93，95%CI：1.45 至 2.57），且饮酒程度每增加一个等级，OR（95%CI）为 1.24（1.13 至 1.35）。