马齿苋水醇提取物对D-半乳糖诱导的衰老小鼠模型糖尿病相关指标的影响
EFFECT OF HYDROALCOHOLIC EXTRACT OF PURSLANE () ON DIABETIC VARIABLES IN D-GALACTOSE INDUCED AGING MOUSE MODEL.
作者信息
Ahangarpour A, Oroojan A A, Khorsandi L, Lamoochi Z
机构信息
Dept. of Physiology, Faculty of Medicine, Physiology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Dept. of Physiology, Faculty of Medicine, Student Research Committee of Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
出版信息
Acta Endocrinol (Buchar). 2018 Jan-Mar;14(1):24-29. doi: 10.4183/aeb.2018.24.
INTRODUCTION
Purslane () has antioxidant effects. The aim of this study was to evaluate the pancreas protective effect of Purslane hydroalcoholic extract in D-galactose induced aging female mouse model.
METHODS
In this experimental study, 72 adult female mice (30 - 35 g) were obtained and divided into 6 groups: control, Purslane hydroalcoholic extract, D-galactose, D-galactose + Purslane hydroalcoholic extract, Aging, Aging + Purslane hydroalcoholic extract. The aging model induced by subcutaneous injection of D-galactose for 45 consecutive days, and Purslane hydroalcoholic extract was orally gavaged in the last 21 days. 24 hours after the last drug and extract administrations, serum samples and pancreas tissues were removed for biochemical and histological assessments.
RESULTS
Glucose decreased in the Purslane, D-galactose + Purslane and Aging + Purslane groups (p<0.05). Insulin and HOMA-IR increased in D-galactose and, Aging groups (p<0.05). Furthermore, administration of hydroalcoholic extract of Purslane improved these parameters in D-galactose and Aging treated mice (p<0.05). Diameter of pancreatic islets decreased in Aging and D-galactose groups and Purslane hydroalcoholic extract administration improved this variable.
CONCLUSIONS
The present results show that Purslane has pancreas protective effects via its hypoglycemic and insulin resistance reducing activity.
引言
马齿苋具有抗氧化作用。本研究旨在评估马齿苋水醇提取物对D-半乳糖诱导的衰老雌性小鼠模型胰腺的保护作用。
方法
在本实验研究中，获取72只成年雌性小鼠（30 - 35克）并分为6组：对照组、马齿苋水醇提取物组、D-半乳糖组、D-半乳糖+马齿苋水醇提取物组、衰老组、衰老+马齿苋水醇提取物组。通过连续45天皮下注射D-半乳糖诱导衰老模型，在最后21天口服给予马齿苋水醇提取物。在最后一次给药和提取物处理24小时后，采集血清样本和胰腺组织进行生化和组织学评估。
结果
马齿苋组、D-半乳糖+马齿苋组和衰老+马齿苋组的血糖降低（p<0.05）。D-半乳糖组和衰老组的胰岛素和HOMA-IR升高（p<0.05）。此外，给予马齿苋水醇提取物改善了D-半乳糖处理和衰老处理小鼠的这些参数（p<0.05）。衰老组和D-半乳糖组的胰岛直径减小，给予马齿苋水醇提取物改善了这一变量。
结论
目前的结果表明，马齿苋通过其降血糖和降低胰岛素抵抗的活性对胰腺具有保护作用。
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