Division of Oral Diseases, Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden.
Division of Oral Diseases, Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden.
Arch Oral Biol. 2019 Aug;104:7-12. doi: 10.1016/j.archoralbio.2019.05.023. Epub 2019 May 24.
In the era of personalized medicine, it is imperative that oral health is integrated into this concept. The oral cavity fosters a highly individualized microbiome that has evolved to promote oral health, and which exists in a dynamic balance with the host. Microecological changes to the biology of the mouth [e.g. in the host diet and lifestyle, or status of the immune system] may drive deleterious shifts in the composition or metabolic activity of the oral microbiome ['dysbiosis']. This review aims to explore how knowledge of the oral microbiome may be utilized for personalized dentistry at the point-of-care.
This is a comprehensive narrative review of the literature, summarizing the perspectives of the authors.
The huge increase in recent knowledge on the ecology and microbiology of the oral cavity generated by 'OMIC' technologies may indeed be clinically translated to support patient care, in terms of prevention, monitoring, risk classification or early diagnosis. The identified clinical applications may not only include dental caries and periodontal disease, but also dental implants and orthodontics. Population-based applications may include systemic health, pregnancy and elderly populations.
Applications of selected oral microbiome and host-related biochemical parameters [e.g. the saliva proteome] for personalized dentistry can be customized for different clinical applications or individual populations, at point-of-care hubs.
在个性化医学时代，将口腔健康纳入这一理念至关重要。口腔内存在着高度个体化的微生物组，这些微生物组的进化促进了口腔健康，并与宿主保持着动态平衡。口腔生物学的微生态变化[例如宿主饮食和生活方式的改变，或免疫系统的状态]可能导致口腔微生物组的组成或代谢活性发生有害变化[即“生态失调”]。本综述旨在探讨如何利用口腔微生物组的知识，在护理点为个性化牙科提供服务。
这是对文献的全面叙述性综述，总结了作者的观点。
通过“OMIC”技术对口腔生态学和微生物学的大量新知识的增加，确实可以在预防、监测、风险分类或早期诊断等方面从临床角度进行转化，以支持患者护理。已确定的临床应用不仅可能包括龋齿和牙周病，还可能包括种植牙和正畸。基于人群的应用可能包括系统健康、妊娠和老年人群。
口腔微生物组和宿主相关生化参数[例如唾液蛋白质组]的特定应用可根据不同的临床应用或个体人群，在护理点中心进行个性化定制。
