Miguel Servet Hospital, Zaragoza, Spain; Eating Disorders Research Unit, Catholic University of Murcia, Murcia, Spain.
Faculty of Medicine, Catholic University of Murcia, Murcia, Spain.
Clin Nutr. 2020 Apr;39(4):1041-1048. doi: 10.1016/j.clnu.2019.05.012. Epub 2019 May 21.
BACKGROUND & AIMS: The alteration of normal biological rhythms, also known as chronodisruption, may be associated with obesity development. For instance, those subject with preference for vespertinity seem to be prone to develop obesity. However, the current hypocaloric dietary treatment of obesity does not take into account these aspects. Therefore, the objective of this trial was to evaluate whether a diet adjusted to patient's chronotype is more effective that the current dietary recommendations.
209 subjects take part on a 3 month randomized, double-blind trial. 104 subjects followed a typical hypocaloric dietary treatment and the other 105 subjects undergone a diet with a daily caloric distribution adjusted to their chronotype. There were no sex or age differences between groups.
Baseline characteristics were similar in both groups. Dropout rate was also similar in both interventions (p = 0.683). Although both groups improved their anthropometrical parameters, the chronotype-adjusted diet group achieved a statistically significant greater reduction in percentage of total body weight loss (%TWL), BMI and waist circumference than the control group (p < 0.010 in all contrasts). The effect on clinical parameters was less pronounced.
This randomized trial has demonstrated for the first time that in overweight/obese subjects, a chronotype-adjusted diet is more effective than the traditional hypocaloric dietary treatment, at least regarding the anthropometrical parameters. Further research will confirm if this intervention is also more effective in the long term.
NCT-ID: #NCT03755674, (available at: http://www.clinicaltrials.gov).
正常生物节律的改变，也称为生物钟紊乱，可能与肥胖的发展有关。例如，那些喜欢傍晚活动的人似乎更容易肥胖。然而，目前针对肥胖的低热量饮食治疗并没有考虑到这些方面。因此，本试验的目的是评估根据患者的生物钟调整的饮食是否比目前的饮食建议更有效。
209 名受试者参加了为期 3 个月的随机、双盲试验。104 名受试者接受了典型的低热量饮食治疗，而另外 105 名受试者接受了根据其生物钟调整的每日热量分布的饮食。两组之间没有性别或年龄差异。
两组的基线特征相似。两组的脱落率也相似（p=0.683）。虽然两组的人体测量参数都有所改善，但与对照组相比，生物钟调整饮食组在总体重减轻百分比（%TWL）、BMI 和腰围方面的下降更为显著（所有对比均 p<0.010）。对临床参数的影响则不那么明显。
这项随机试验首次证明，在超重/肥胖患者中，生物钟调整饮食比传统的低热量饮食治疗更有效，至少在人体测量参数方面如此。进一步的研究将证实这种干预在长期内是否也更有效。
NCT-ID：#NCT03755674，（可在 http://www.clinicaltrials.gov 上获取）。
