运输载体连接 - 囊泡如何被细胞器捕获。

Transport carrier tethering - how vesicles are captured by organelles.

机构信息

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.

出版信息

Curr Opin Cell Biol. 2019 Aug;59:140-146. doi: 10.1016/j.ceb.2019.04.010. Epub 2019 May 30.

DOI:10.1016/j.ceb.2019.04.010

Abstract

All cells contain numerous membrane-bound organelles that carry out specific functions. These compartments do not, however, act in isolation. Some are in direct contact via membrane contact sites, while others exchange material via specific vesicles or tubular carriers laden with cargo. The term tethering in the context of this review is used to describe the primary recognition and docking of transport carriers with acceptor organelles that occurs before SNARE engagement and membrane fusion. However, it is important to note that other tethering events occur, for example, between organelles in direct contact, which do not lead to fusion.

摘要

所有细胞都包含许多执行特定功能的膜结合细胞器。然而，这些隔室并非孤立运作。有些通过膜接触位点直接接触，而有些则通过特定的含有货物的小泡或管状载体进行物质交换。在本篇综述中，术语“ tethering”用于描述在 SNARE 结合和膜融合之前，运输载体与受体细胞器的主要识别和对接。然而，需要注意的是，还会发生其他 tethering 事件，例如在不导致融合的直接接触的细胞器之间。