School of Health Sciences, Universiti Sains Malaysia, Health Campus, 16150, Kubang Kerian, Kelantan, Malaysia.
Forensic Science Laboratory, Criminal Investigation Department, Ghana Police Service, 00233, Accra, Ghana.
Int J Legal Med. 2020 Jul;134(4):1313-1315. doi: 10.1007/s00414-019-02099-w. Epub 2019 Jun 1.
In this study, 268 samples for unrelated males belonging to the five major human subpopulation groups in Ghana (Akan, Ewe, Mole-Dagbon, Ga-Dangme and Guang) were genetically characterised for 23 Y chromosome short tandem repeat (STR) loci using the Powerplex® Y23 STR kit. A total of 263 complete haplotypes were recorded of which 258 were unique. The haplotype diversity, discriminating capacity and match probability for the pooled population data were 0.9998, 0.9627 and 0.0039, respectively. The pairwise genetic distance (R) for the Ghanaian datasets and other reference populations deposited in the Y-STR Haplotype Reference Database (YHRD) were estimated and mapped using multidimensional scaling (MDS) plot. The Guang and Ewe were significantly different from the Akan, Mole-Dagbon and Ga-Dangme. However, the five Ghanaian datasets were all plotted close together with other African populations in the MDS data mapping.
在这项研究中，使用 Powerplex® Y23 STR 试剂盒对加纳五个主要人群（阿坎、埃维、莫勒-达贡、加-当梅和广东）的 268 名无关男性样本进行了 23 个 Y 染色体短串联重复（STR）位点的基因特征分析。共记录了 263 个完整的单倍型，其中 258 个是独特的。总体人群数据的单倍型多样性、区分能力和匹配概率分别为 0.9998、0.9627 和 0.0039。使用多维尺度（MDS）图估计和映射加纳数据集和 Y-STR 单倍型参考数据库（YHRD）中其他参考人群的成对遗传距离（R）。广东和埃维与阿坎、莫勒-达贡和加-当梅有显著差异。然而，在 MDS 数据映射中，这五个加纳数据集都与其他非洲人群紧密地聚集在一起。
