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α-亚麻酸对致敏大鼠气管反应性、肺部炎症及免疫标志物的影响。

The effect of alpha linolenic acid on tracheal responsiveness, lung inflammation, and immune markers in sensitized rats.

作者信息

Kaveh Mahsa, Eftekhar Naeima, Boskabady Mohammad Hossein

机构信息

Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.

Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Iran.

出版信息

Iran J Basic Med Sci. 2019 Mar;22(3):255-261. doi: 10.22038/ijbms.2019.27381.6684.

DOI:10.22038/ijbms.2019.27381.6684
PMID:31156785
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6528709/
Abstract

OBJECTIVES

The effects of alpha linolenic acid (ALA) on tracheal responsiveness (TR), total protein (TP), phospholipase A2 (PLA2), immunoglobulin E (IgE), interleukin 4 (IL-4), interferon gamma (INF-γ) level and INF-γ/IL4 ratio in bronchoalveolar lavage fluid (BALF) of sensitized rats were examined.

MATERIALS AND METHODS

TR to methacholine and ovalbumin (OA), BALF levels of TP, PLA2 and IgE as well as IL-4, INF-γ and INF-γ/IL4 ratio were measured in control group (non-sensitized, group C), sensitized rats to OA (group S), S groups treated with two concentrations of ALA and dexamethasone group.

RESULTS

TR to methacholine and OA, BALF levels of TP, PLA2, IgE and IL-4 were significantly increased but BALF level of INF-γ and INF-γ/IL4 ratio decreased in group S compared to group C (<0.001 for all cases). Treated S groups with dexamethasone and both concentrations of ALA lead to significant decrease in TR to methacholine and OA, BALF levels of TP, PLA2, IgE and IL-4 compared to group S (<0.001 for all case). The effects of all concentrations of ALA on INF-γ, IL-4 and INF-γ/IL4 ratio and also the effect of its highest concentration on TP and IgE level were significantly higher than dexamethasone treatment (<0.001 for all cases).

CONCLUSION

Results showed an immune modulatory effect of the ALA that increased INF-γ, INF-γ/IL4 ratio (as an index of Th1/Th2) and decreased IL-4 in sensitized rats. ALA also showed preventive effect on inflammatory markers and tracheal responsiveness in sensitized animals comparable to the effect of dexamethasone.

摘要

目的

研究α-亚麻酸（ALA）对致敏大鼠支气管肺泡灌洗液（BALF）中气管反应性（TR）、总蛋白（TP）、磷脂酶A2（PLA2）、免疫球蛋白E（IgE）、白细胞介素4（IL-4）、干扰素γ（INF-γ）水平及INF-γ/IL4比值的影响。

材料与方法

测定对照组（未致敏，C组）、致敏于卵清蛋白（OA）的大鼠（S组）、用两种浓度ALA处理的S组以及地塞米松组对乙酰甲胆碱和卵清蛋白（OA）的TR、BALF中TP、PLA2和IgE水平以及IL-4、INF-γ和INF-γ/IL4比值。

结果

与C组相比，S组对乙酰甲胆碱和OA的TR、BALF中TP、PLA2、IgE和IL-4水平显著升高，但BALF中INF-γ水平和INF-γ/IL4比值降低（所有情况P<0.001）。与S组相比，用地塞米松和两种浓度ALA处理的S组导致对乙酰甲胆碱和OA的TR、BALF中TP、PLA2、IgE和IL-4水平显著降低（所有情况P<0.001）。所有浓度ALA对INF-γ、IL-4和INF-γ/IL4比值的影响以及其最高浓度对TP和IgE水平的影响均显著高于地塞米松治疗（所有情况P<0.001）。

结论

结果显示ALA在致敏大鼠中具有免疫调节作用，可增加INF-γ、INF-γ/IL4比值（作为Th1/Th2的指标）并降低IL-4。ALA对致敏动物的炎症标志物和气管反应性也显示出与地塞米松相当的预防作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb8f/6528709/8de90c5d8d3d/IJBMS-22-255-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb8f/6528709/38a1a300bcac/IJBMS-22-255-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb8f/6528709/7a79b30a77a9/IJBMS-22-255-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb8f/6528709/3be3302105d7/IJBMS-22-255-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb8f/6528709/35dffa2151a4/IJBMS-22-255-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb8f/6528709/9d557bff34a4/IJBMS-22-255-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb8f/6528709/8de90c5d8d3d/IJBMS-22-255-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb8f/6528709/38a1a300bcac/IJBMS-22-255-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb8f/6528709/7a79b30a77a9/IJBMS-22-255-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb8f/6528709/3be3302105d7/IJBMS-22-255-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb8f/6528709/35dffa2151a4/IJBMS-22-255-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb8f/6528709/9d557bff34a4/IJBMS-22-255-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb8f/6528709/8de90c5d8d3d/IJBMS-22-255-g006.jpg

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