Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
PLoS One. 2013 Jul 26;8(7):e69940. doi: 10.1371/journal.pone.0069940. Print 2013.
A number of studies evaluated the association of intracellular adhesion molecule-1 (ICAM-1) K469E (rs5498, A/G) gene polymorphism with diabetic microvascular complications (DMI) including diabetic nephropathy (DN) and diabetic retinopathy (DR) in different populations. However, the results of individual studies remain conflicting.
A comprehensive search was conducted to identify all eligible studies of the above-mentioned associations. The pooled odds ratios (ORs) and 95% confidence intervals (CIs) were assessed using the fixed or random effect model.
Seven studies involving 3411 subjects were included. Overall, the meta-analysis showed a significant association of the A allele with increased risk of DMI susceptibility in a recessive model (OR = 1.37, 95% CI 1.04-1.80, P = 0.02). In the subgroup analysis stratified by ethnicity, significant association was found in Asians but not in Caucasians (OR = 1.78, 95% CI 1.13-2.81, P = 0.01; OR = 1.10, 95% CI 0.79-1.54, P = 0.58, respectively). Moreover, it showed a significant association between the A allele and risk of DN in a recessive model (OR = 1.25, 95% CI 1.02-1.55, P = 0.04).
This meta-analysis suggested that the K469E polymorphism in ICAM-1 gene might affect individual susceptibility to DMI and showed a discrepancy in different ethnicities. Further investigations are needed to validate the association.
多项研究评估了细胞间黏附分子-1（ICAM-1）K469E（rs5498，A/G）基因多态性与糖尿病微血管并发症（DMI），包括糖尿病肾病（DN）和糖尿病视网膜病变（DR）在不同人群中的关系。然而，个别研究的结果仍存在争议。
我们进行了全面的检索，以确定所有符合上述关联的研究。使用固定或随机效应模型评估汇总的比值比（OR）和 95％置信区间（CI）。
共有 7 项研究涉及 3411 名受试者。总体而言，荟萃分析显示在隐性模型中 A 等位基因与 DMI 易感性增加相关（OR=1.37，95％CI 1.04-1.80，P=0.02）。在按种族分层的亚组分析中，亚洲人群中存在显著相关性，但在高加索人群中没有（OR=1.78，95％CI 1.13-2.81，P=0.01；OR=1.10，95％CI 0.79-1.54，P=0.58）。此外，在隐性模型中，A 等位基因与 DN 风险之间存在显著相关性（OR=1.25，95％CI 1.02-1.55，P=0.04）。
这项荟萃分析表明，ICAM-1 基因的 K469E 多态性可能影响个体对 DMI 的易感性，并且在不同种族之间存在差异。需要进一步的研究来验证这种关联。
